Inhibitory Effects of Resveratrol on the Epstein-Barr Virus Lytic Cycle

Reactivation of Epstein-Barr virus (EBV) from latency to the lytic cycle is required for the production of viral particles. Here, we examine the capacity of resveratrol to inhibit the EBV lytic cycle. Our results show that resveratrol inhibits the transcription of EBV immediate early genes, the expr...

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Autores principales: Yiu, Ching-Yi, Chen, Shih-Ying, Chang, Li-Kwan, Chiu, Ya-Fang, Lin, Tsuey-Pin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259417/
https://www.ncbi.nlm.nih.gov/pubmed/20948499
http://dx.doi.org/10.3390/molecules15107115
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author Yiu, Ching-Yi
Chen, Shih-Ying
Chang, Li-Kwan
Chiu, Ya-Fang
Lin, Tsuey-Pin
author_facet Yiu, Ching-Yi
Chen, Shih-Ying
Chang, Li-Kwan
Chiu, Ya-Fang
Lin, Tsuey-Pin
author_sort Yiu, Ching-Yi
collection PubMed
description Reactivation of Epstein-Barr virus (EBV) from latency to the lytic cycle is required for the production of viral particles. Here, we examine the capacity of resveratrol to inhibit the EBV lytic cycle. Our results show that resveratrol inhibits the transcription of EBV immediate early genes, the expression of EBV lytic proteins, including Rta, Zta, and EA-D and reduces viron production, suggesting that this compound may be useful for preventing the proliferation of the virus.
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spelling pubmed-62594172018-12-06 Inhibitory Effects of Resveratrol on the Epstein-Barr Virus Lytic Cycle Yiu, Ching-Yi Chen, Shih-Ying Chang, Li-Kwan Chiu, Ya-Fang Lin, Tsuey-Pin Molecules Article Reactivation of Epstein-Barr virus (EBV) from latency to the lytic cycle is required for the production of viral particles. Here, we examine the capacity of resveratrol to inhibit the EBV lytic cycle. Our results show that resveratrol inhibits the transcription of EBV immediate early genes, the expression of EBV lytic proteins, including Rta, Zta, and EA-D and reduces viron production, suggesting that this compound may be useful for preventing the proliferation of the virus. MDPI 2010-10-14 /pmc/articles/PMC6259417/ /pubmed/20948499 http://dx.doi.org/10.3390/molecules15107115 Text en © 2010 by the authors; http://creativecommons.org/licenses/by/3.0/ licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Yiu, Ching-Yi
Chen, Shih-Ying
Chang, Li-Kwan
Chiu, Ya-Fang
Lin, Tsuey-Pin
Inhibitory Effects of Resveratrol on the Epstein-Barr Virus Lytic Cycle
title Inhibitory Effects of Resveratrol on the Epstein-Barr Virus Lytic Cycle
title_full Inhibitory Effects of Resveratrol on the Epstein-Barr Virus Lytic Cycle
title_fullStr Inhibitory Effects of Resveratrol on the Epstein-Barr Virus Lytic Cycle
title_full_unstemmed Inhibitory Effects of Resveratrol on the Epstein-Barr Virus Lytic Cycle
title_short Inhibitory Effects of Resveratrol on the Epstein-Barr Virus Lytic Cycle
title_sort inhibitory effects of resveratrol on the epstein-barr virus lytic cycle
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259417/
https://www.ncbi.nlm.nih.gov/pubmed/20948499
http://dx.doi.org/10.3390/molecules15107115
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