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Pancreatic Lipase Inhibition by C-Glycosidic Flavones Isolated from Eremochloa ophiuroides

Activity-guided fractionation of a methanolic extract of the leaves of Eremochloa ophiuroides (centipede grass) using a pancreatic lipase inhibitory assay led to the isolation and identification of a new C-glycosidic flavone, luteolin 6-C-β-D-boivinopyranoside (1), as well as eight known compounds....

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Detalles Bibliográficos
Autores principales: Lee, Eun Mi, Lee, Seung Sik, Chung, Byung Yeoup, Cho, Jae-Young, Lee, In Chul, Ahn, So Ra, Jang, Soo Jeung, Kim, Tae Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259569/
https://www.ncbi.nlm.nih.gov/pubmed/21081855
http://dx.doi.org/10.3390/molecules15118251
Descripción
Sumario:Activity-guided fractionation of a methanolic extract of the leaves of Eremochloa ophiuroides (centipede grass) using a pancreatic lipase inhibitory assay led to the isolation and identification of a new C-glycosidic flavone, luteolin 6-C-β-D-boivinopyranoside (1), as well as eight known compounds. The structures of these compounds were established on the basis of interpretation of their spectroscopic data. Among these isolates, the C-glycosidic flavones 1–5 showed potent inhibitory effects on pancreatic lipase, with IC(50) values ranging from 18.5 ± 2.6 to 50.5 ± 3.9 μM.