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Pancreatic Lipase Inhibition by C-Glycosidic Flavones Isolated from Eremochloa ophiuroides

Activity-guided fractionation of a methanolic extract of the leaves of Eremochloa ophiuroides (centipede grass) using a pancreatic lipase inhibitory assay led to the isolation and identification of a new C-glycosidic flavone, luteolin 6-C-β-D-boivinopyranoside (1), as well as eight known compounds....

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Autores principales: Lee, Eun Mi, Lee, Seung Sik, Chung, Byung Yeoup, Cho, Jae-Young, Lee, In Chul, Ahn, So Ra, Jang, Soo Jeung, Kim, Tae Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259569/
https://www.ncbi.nlm.nih.gov/pubmed/21081855
http://dx.doi.org/10.3390/molecules15118251
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author Lee, Eun Mi
Lee, Seung Sik
Chung, Byung Yeoup
Cho, Jae-Young
Lee, In Chul
Ahn, So Ra
Jang, Soo Jeung
Kim, Tae Hoon
author_facet Lee, Eun Mi
Lee, Seung Sik
Chung, Byung Yeoup
Cho, Jae-Young
Lee, In Chul
Ahn, So Ra
Jang, Soo Jeung
Kim, Tae Hoon
author_sort Lee, Eun Mi
collection PubMed
description Activity-guided fractionation of a methanolic extract of the leaves of Eremochloa ophiuroides (centipede grass) using a pancreatic lipase inhibitory assay led to the isolation and identification of a new C-glycosidic flavone, luteolin 6-C-β-D-boivinopyranoside (1), as well as eight known compounds. The structures of these compounds were established on the basis of interpretation of their spectroscopic data. Among these isolates, the C-glycosidic flavones 1–5 showed potent inhibitory effects on pancreatic lipase, with IC(50) values ranging from 18.5 ± 2.6 to 50.5 ± 3.9 μM.
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spelling pubmed-62595692018-12-06 Pancreatic Lipase Inhibition by C-Glycosidic Flavones Isolated from Eremochloa ophiuroides Lee, Eun Mi Lee, Seung Sik Chung, Byung Yeoup Cho, Jae-Young Lee, In Chul Ahn, So Ra Jang, Soo Jeung Kim, Tae Hoon Molecules Article Activity-guided fractionation of a methanolic extract of the leaves of Eremochloa ophiuroides (centipede grass) using a pancreatic lipase inhibitory assay led to the isolation and identification of a new C-glycosidic flavone, luteolin 6-C-β-D-boivinopyranoside (1), as well as eight known compounds. The structures of these compounds were established on the basis of interpretation of their spectroscopic data. Among these isolates, the C-glycosidic flavones 1–5 showed potent inhibitory effects on pancreatic lipase, with IC(50) values ranging from 18.5 ± 2.6 to 50.5 ± 3.9 μM. MDPI 2010-11-16 /pmc/articles/PMC6259569/ /pubmed/21081855 http://dx.doi.org/10.3390/molecules15118251 Text en © 2010 by the authors; http://creativecommons.org/licenses/by/3.0/ licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Lee, Eun Mi
Lee, Seung Sik
Chung, Byung Yeoup
Cho, Jae-Young
Lee, In Chul
Ahn, So Ra
Jang, Soo Jeung
Kim, Tae Hoon
Pancreatic Lipase Inhibition by C-Glycosidic Flavones Isolated from Eremochloa ophiuroides
title Pancreatic Lipase Inhibition by C-Glycosidic Flavones Isolated from Eremochloa ophiuroides
title_full Pancreatic Lipase Inhibition by C-Glycosidic Flavones Isolated from Eremochloa ophiuroides
title_fullStr Pancreatic Lipase Inhibition by C-Glycosidic Flavones Isolated from Eremochloa ophiuroides
title_full_unstemmed Pancreatic Lipase Inhibition by C-Glycosidic Flavones Isolated from Eremochloa ophiuroides
title_short Pancreatic Lipase Inhibition by C-Glycosidic Flavones Isolated from Eremochloa ophiuroides
title_sort pancreatic lipase inhibition by c-glycosidic flavones isolated from eremochloa ophiuroides
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259569/
https://www.ncbi.nlm.nih.gov/pubmed/21081855
http://dx.doi.org/10.3390/molecules15118251
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