A Novel 18-Norclerodane Diterpenoid from the Roots of Tinospora sagittata var. yunnanensis

A novel 18-nor-clerodane diterpenoid named sagitone (1) was isolated from the 95% ethanol extract of dry roots of Tinospora sagittata var. yunnanensis together with the five known diterpenoids columbin (2), palmatoside C (3), fibleucin (4), tinophylloloside (5) and epitinophylloloside (6). The struc...

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Detalles Bibliográficos
Autores principales: Huang, Xiang-Zhong, Cheng, Chun-Mei, Dai, Yun, Fu, Guang-Miao, Guo, Jun-Ming, Yin, Yan, Liang, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259588/
https://www.ncbi.nlm.nih.gov/pubmed/21081856
http://dx.doi.org/10.3390/molecules15118360
Descripción
Sumario:A novel 18-nor-clerodane diterpenoid named sagitone (1) was isolated from the 95% ethanol extract of dry roots of Tinospora sagittata var. yunnanensis together with the five known diterpenoids columbin (2), palmatoside C (3), fibleucin (4), tinophylloloside (5) and epitinophylloloside (6). The structure of the new compound 1 was determined based on MS, IR, 1D and 2D NMR spectral data. The compounds 1~6 did not show significant cytotoxic activity against cancer cell lines K562 and HL-60.

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