A Novel 18-Norclerodane Diterpenoid from the Roots of Tinospora sagittata var. yunnanensis

A novel 18-nor-clerodane diterpenoid named sagitone (1) was isolated from the 95% ethanol extract of dry roots of Tinospora sagittata var. yunnanensis together with the five known diterpenoids columbin (2), palmatoside C (3), fibleucin (4), tinophylloloside (5) and epitinophylloloside (6). The struc...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Xiang-Zhong, Cheng, Chun-Mei, Dai, Yun, Fu, Guang-Miao, Guo, Jun-Ming, Yin, Yan, Liang, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2010
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259588/
https://www.ncbi.nlm.nih.gov/pubmed/21081856
http://dx.doi.org/10.3390/molecules15118360
_version_ 1783374712918769664
author Huang, Xiang-Zhong
Cheng, Chun-Mei
Dai, Yun
Fu, Guang-Miao
Guo, Jun-Ming
Yin, Yan
Liang, Hui
author_facet Huang, Xiang-Zhong
Cheng, Chun-Mei
Dai, Yun
Fu, Guang-Miao
Guo, Jun-Ming
Yin, Yan
Liang, Hui
author_sort Huang, Xiang-Zhong
collection PubMed
description A novel 18-nor-clerodane diterpenoid named sagitone (1) was isolated from the 95% ethanol extract of dry roots of Tinospora sagittata var. yunnanensis together with the five known diterpenoids columbin (2), palmatoside C (3), fibleucin (4), tinophylloloside (5) and epitinophylloloside (6). The structure of the new compound 1 was determined based on MS, IR, 1D and 2D NMR spectral data. The compounds 1~6 did not show significant cytotoxic activity against cancer cell lines K562 and HL-60.
format Online
Article
Text
id pubmed-6259588
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-62595882018-12-06 A Novel 18-Norclerodane Diterpenoid from the Roots of Tinospora sagittata var. yunnanensis Huang, Xiang-Zhong Cheng, Chun-Mei Dai, Yun Fu, Guang-Miao Guo, Jun-Ming Yin, Yan Liang, Hui Molecules Article A novel 18-nor-clerodane diterpenoid named sagitone (1) was isolated from the 95% ethanol extract of dry roots of Tinospora sagittata var. yunnanensis together with the five known diterpenoids columbin (2), palmatoside C (3), fibleucin (4), tinophylloloside (5) and epitinophylloloside (6). The structure of the new compound 1 was determined based on MS, IR, 1D and 2D NMR spectral data. The compounds 1~6 did not show significant cytotoxic activity against cancer cell lines K562 and HL-60. MDPI 2010-11-16 /pmc/articles/PMC6259588/ /pubmed/21081856 http://dx.doi.org/10.3390/molecules15118360 Text en © 2010 by the authors; http://creativecommons.org/licenses/by/3.0/ licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Huang, Xiang-Zhong
Cheng, Chun-Mei
Dai, Yun
Fu, Guang-Miao
Guo, Jun-Ming
Yin, Yan
Liang, Hui
A Novel 18-Norclerodane Diterpenoid from the Roots of Tinospora sagittata var. yunnanensis
title A Novel 18-Norclerodane Diterpenoid from the Roots of Tinospora sagittata var. yunnanensis
title_full A Novel 18-Norclerodane Diterpenoid from the Roots of Tinospora sagittata var. yunnanensis
title_fullStr A Novel 18-Norclerodane Diterpenoid from the Roots of Tinospora sagittata var. yunnanensis
title_full_unstemmed A Novel 18-Norclerodane Diterpenoid from the Roots of Tinospora sagittata var. yunnanensis
title_short A Novel 18-Norclerodane Diterpenoid from the Roots of Tinospora sagittata var. yunnanensis
title_sort novel 18-norclerodane diterpenoid from the roots of tinospora sagittata var. yunnanensis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259588/
https://www.ncbi.nlm.nih.gov/pubmed/21081856
http://dx.doi.org/10.3390/molecules15118360
work_keys_str_mv AT huangxiangzhong anovel18norclerodanediterpenoidfromtherootsoftinosporasagittatavaryunnanensis
AT chengchunmei anovel18norclerodanediterpenoidfromtherootsoftinosporasagittatavaryunnanensis
AT daiyun anovel18norclerodanediterpenoidfromtherootsoftinosporasagittatavaryunnanensis
AT fuguangmiao anovel18norclerodanediterpenoidfromtherootsoftinosporasagittatavaryunnanensis
AT guojunming anovel18norclerodanediterpenoidfromtherootsoftinosporasagittatavaryunnanensis
AT yinyan anovel18norclerodanediterpenoidfromtherootsoftinosporasagittatavaryunnanensis
AT lianghui anovel18norclerodanediterpenoidfromtherootsoftinosporasagittatavaryunnanensis
AT huangxiangzhong novel18norclerodanediterpenoidfromtherootsoftinosporasagittatavaryunnanensis
AT chengchunmei novel18norclerodanediterpenoidfromtherootsoftinosporasagittatavaryunnanensis
AT daiyun novel18norclerodanediterpenoidfromtherootsoftinosporasagittatavaryunnanensis
AT fuguangmiao novel18norclerodanediterpenoidfromtherootsoftinosporasagittatavaryunnanensis
AT guojunming novel18norclerodanediterpenoidfromtherootsoftinosporasagittatavaryunnanensis
AT yinyan novel18norclerodanediterpenoidfromtherootsoftinosporasagittatavaryunnanensis
AT lianghui novel18norclerodanediterpenoidfromtherootsoftinosporasagittatavaryunnanensis

Ejemplares similares