Cargando…

Synthesis, Characterization and Biological Evaluation of Succinate Prodrugs of Curcuminoids for Colon Cancer Treatment

A novel series of succinyl derivatives of three curcuminoids were synthesized as potential prodrugs. Symmetrical (curcumin and bisdesmethoxycurcumin) and unsymmetrical (desmethoxycurcumin) curcuminoids were prepared through aldol condensation of 2,4-pentanedione with different benzaldehydes. Esterif...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wichitnithad, Wisut, Nimmannit, Ubonthip, Wacharasindhu, Sumrit, Rojsitthisak, Pornchai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259653/ https://www.ncbi.nlm.nih.gov/pubmed/21343891 http://dx.doi.org/10.3390/molecules16021888

Ejemplares similares

A stability-indicating UPLC method for the determination of curcumin diethyl disuccinate, an ester prodrug of curcumin, in raw materials
por: Ratnatilaka Na Bhuket, Pahweenvaj, et al.
Publicado: (2020)

Scale-Up Synthesis and In Vivo Anti-Tumor Activity of Curcumin Diethyl Disuccinate, an Ester Prodrug of Curcumin, in HepG2-Xenograft Mice
por: Muangnoi, Chawanphat, et al.
Publicado: (2019)

An update on the current status and prospects of nitrosation pathways and possible root causes of nitrosamine formation in various pharmaceuticals
por: Wichitnithad, Wisut, et al.
Publicado: (2023)

A Stability-Indicating Assay for Tetrahydrocurcumin-Diglutaric Acid and Its Applications to Evaluate Bioaccessibility in an In Vitro Digestive Model
por: Jongjitphisut, Nattapong, et al.
Publicado: (2023)

Development and Validation of Liquid Chromatography-Tandem Mass Spectrometry Method for Simple Analysis of Sumatriptan and its Application in Bioequivalence Study
por: Wichitnithad, Wisut, et al.
Publicado: (2020)

Development of a Sensitive Headspace Gas Chromatography–Mass Spectrometry Method for the Simultaneous Determination of Nitrosamines in Losartan Active Pharmaceutical Ingredients
por: Wichitnithad, Wisut, et al.
Publicado: (2021)

Synthesis and Biological Evaluation of Novel Curcuminoid Derivatives
por: Cao, Ya-Kun, et al.
Publicado: (2014)

Interspecies differences in stability kinetics and plasma esterases involved in hydrolytic activation of curcumin diethyl disuccinate, a prodrug of curcumin
por: Ratnatilaka Na Bhuket, Pahweenvaj, et al.
Publicado: (2019)

Synthesis of Curcuminoids and Evaluation of Their Cytotoxic and Antioxidant Properties
por: Lozada-García, María Concepción, et al.
Publicado: (2017)

A New Family of Homoleptic Copper Complexes of Curcuminoids: Synthesis, Characterization and Biological Properties
por: Meza-Morales, William, et al.
Publicado: (2019)

In Vitro Inhibitory Effects of Cyandin-3-rutinoside on Pancreatic α-Amylase and Its Combined Effect with Acarbose
por: Akkarachiyasit, Sarinya, et al.
Publicado: (2011)

Synthesis and Evaluation of Curcuminoid Analogues as Antioxidant and Antibacterial Agents
por: Emam, Dalia R., et al.
Publicado: (2017)

Design, Synthesis and Evaluation of Novel Derivatives of Curcuminoids with Cytotoxicity
por: Chen, Chen-Yin, et al.
Publicado: (2021)

Molecular Insight into the Anti-Inflammatory Effects of the Curcumin Ester Prodrug Curcumin Diglutaric Acid In Vitro and In Vivo
por: Phumsuay, Rianthong, et al.
Publicado: (2020)

Synthesis of curcuminoid-imprinted polymers applied to the solid-phase extraction of curcuminoids from turmeric samples
por: Thongchai, Wisanu, et al.
Publicado: (2018)

Anti-Inflammatory Activity of Oxyresveratrol Tetraacetate, an Ester Prodrug of Oxyresveratrol, on Lipopolysaccharide-Stimulated RAW264.7 Macrophage Cells
por: Thaweesest, Wuttinont, et al.
Publicado: (2022)

In silico anti-SARS-CoV-2, antiplasmodial, antioxidant, and antimicrobial activities of crude extracts and homopterocarpin from heartwood of Pterocarpus macrocarpus Kurz.
por: Wahyuni, Dwi Kusuma, et al.
Publicado: (2023)

The Effect of Formulation of Curcuminoids on Their Metabolism by Human Colonic Microbiota
por: Bresciani, Letizia, et al.
Publicado: (2020)

Curcumin Diglutaric Acid, a Prodrug of Curcumin Reduces Pain Hypersensitivity in Chronic Constriction Injury of Sciatic Nerve Induced-Neuropathy in Mice
por: Limcharoen, Thanchanok, et al.
Publicado: (2020)

Physicochemical investigation of a novel curcumin diethyl γ-aminobutyrate, a carbamate ester prodrug of curcumin with enhanced anti-neuroinflammatory activity
por: Jithavech, Ponsiree, et al.
Publicado: (2022)

Improved Synthesis of Asymmetric Curcuminoids and Their Assessment as Antioxidants
por: Cheng, Yang-Je, et al.
Publicado: (2022)

Synthesis, Biological Evaluation, and Pharmacokinetic Study of Novel Liguzinediol Prodrugs
por: Liu, Zheng, et al.
Publicado: (2013)

Ethanolic Fenugreek Extract: Its Molecular Mechanisms against Skin Aging and the Enhanced Functions by Nanoencapsulation
por: Eaknai, Waleewan, et al.
Publicado: (2022)

Cell-permeable succinate prodrugs bypass mitochondrial complex I deficiency
por: Ehinger, Johannes K., et al.
Publicado: (2016)

Curcumin diethyl disuccinate, a prodrug of curcumin, enhances anti-proliferative effect of curcumin against HepG2 cells via apoptosis induction
por: Muangnoi, Chawanphat, et al.
Publicado: (2019)

Protective Effects of Curcumin Ester Prodrug, Curcumin Diethyl Disuccinate against H(2)O(2)-Induced Oxidative Stress in Human Retinal Pigment Epithelial Cells: Potential Therapeutic Avenues for Age-Related Macular Degeneration
por: Muangnoi, Chawanphat, et al.
Publicado: (2019)

Synthesis of Aromatic Retinoids and Curcuminoids and Evaluation of their Antiproliferative, Antiradical, and Anti‐inflammatory Activities
por: Morzycki, Jacek W., et al.
Publicado: (2016)

Synthesis of Thiophene and NO-Curcuminoids for Antiinflammatory and Anti-Cancer Activities
por: Ahmed, Mahera M., et al.
Publicado: (2013)

Protective Effects of a Lutein Ester Prodrug, Lutein Diglutaric Acid, against H(2)O(2)-Induced Oxidative Stress in Human Retinal Pigment Epithelial Cells
por: Muangnoi, Chawanphat, et al.
Publicado: (2021)

Design, synthesis and biological evaluation of phosphorodiamidate prodrugs of antiviral and anticancer nucleosides
por: McGuigan, Christopher, et al.
Publicado: (2013)

TSPO Ligand-Methotrexate Prodrug Conjugates: Design, Synthesis, and Biological Evaluation
por: Laquintana, Valentino, et al.
Publicado: (2016)

Expedient synthesis and biological evaluation of alkenyl acyclic nucleoside phosphonate prodrugs
por: Pileggi, Elisa, et al.
Publicado: (2018)

Synthesis of Novel Bis-imino and Bis-amino Curcuminoids for Evaluation of Their Anticancer and Antibacterial Activity
por: Mathur, Priyanka, et al.
Publicado: (2022)

Synthesis of Novel Aza‐aromatic Curcuminoids with Improved Biological Activities towards Various Cancer Cell Lines
por: Theppawong, Atiruj, et al.
Publicado: (2018)

Synthesis of Carrier-Free Paclitaxel–Curcumin Nanoparticles: The Role of Curcuminoids
por: Karaosmanoglu, Sena, et al.
Publicado: (2022)

Curcuminoid Chalcones: Synthesis, Stability, and New Neuroprotective and Sonosensitising Activities
por: Olender, Dorota, et al.
Publicado: (2023)

Spacer/Linker Based Synthesis and Biological Evaluation of Mutual Prodrugs as Antiinflammatory Agents
por: Velingkar, V. S., et al.
Publicado: (2010)

Synthesis, Biological Evaluation and Low-Toxic Formulation Development of Glycosylated Paclitaxel Prodrugs
por: Mao, Yukang, et al.
Publicado: (2018)

Self-Assembled Thermoresponsive Nanogel from Grafted Hyaluronic Acid as a Biocompatible Delivery Platform for Curcumin with Enhanced Drug Loading and Biological Activities
por: Luckanagul, Jittima Amie, et al.
Publicado: (2021)

Synthesis and Biochemical Evaluation of Baicalein Prodrugs
por: Son, Sang-Hyun, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_oerg4ttfpf239m1s7f6psbd60k