Synthesis and Biological Evaluation of Novel Acenaphthene Derivatives as Potential Antitumor Agents

Twelve novel acenaphthene derivatives have been synthesized. The structures of all compounds were confirmed by (1)H-NMR, MS and elemental analysis. Their antitumor activities were evaluated in six human solid tumor cell lines, namely non-small cell lung cancer (H460), human colon adenocarcinoma (SW4...

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Detalles Bibliográficos
Autores principales: Xie, Yong-Mei, Deng, Yi, Dai, Xiao-Yun, Liu, Jie, Ouyang, Liang, Wei, Yu-Quan, Zhao, Ying-Lan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259654/
https://www.ncbi.nlm.nih.gov/pubmed/21415833
http://dx.doi.org/10.3390/molecules16032519
Descripción
Sumario:Twelve novel acenaphthene derivatives have been synthesized. The structures of all compounds were confirmed by (1)H-NMR, MS and elemental analysis. Their antitumor activities were evaluated in six human solid tumor cell lines, namely non-small cell lung cancer (H460), human colon adenocarcinoma (SW480), human breast cancer cell (MDA-MB-468 and SKRB-3), human melanoma cell (A375) and human pancreatic cancer (BxPC-3). Among them, compound 3c shows the best antitumor activity against SKRB-3 cell line, as high as the positive control adriamycin.

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