Synthesis and Biological Evaluation of Novel Acenaphthene Derivatives as Potential Antitumor Agents

Twelve novel acenaphthene derivatives have been synthesized. The structures of all compounds were confirmed by (1)H-NMR, MS and elemental analysis. Their antitumor activities were evaluated in six human solid tumor cell lines, namely non-small cell lung cancer (H460), human colon adenocarcinoma (SW4...

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Autores principales: Xie, Yong-Mei, Deng, Yi, Dai, Xiao-Yun, Liu, Jie, Ouyang, Liang, Wei, Yu-Quan, Zhao, Ying-Lan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259654/
https://www.ncbi.nlm.nih.gov/pubmed/21415833
http://dx.doi.org/10.3390/molecules16032519
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author Xie, Yong-Mei
Deng, Yi
Dai, Xiao-Yun
Liu, Jie
Ouyang, Liang
Wei, Yu-Quan
Zhao, Ying-Lan
author_facet Xie, Yong-Mei
Deng, Yi
Dai, Xiao-Yun
Liu, Jie
Ouyang, Liang
Wei, Yu-Quan
Zhao, Ying-Lan
author_sort Xie, Yong-Mei
collection PubMed
description Twelve novel acenaphthene derivatives have been synthesized. The structures of all compounds were confirmed by (1)H-NMR, MS and elemental analysis. Their antitumor activities were evaluated in six human solid tumor cell lines, namely non-small cell lung cancer (H460), human colon adenocarcinoma (SW480), human breast cancer cell (MDA-MB-468 and SKRB-3), human melanoma cell (A375) and human pancreatic cancer (BxPC-3). Among them, compound 3c shows the best antitumor activity against SKRB-3 cell line, as high as the positive control adriamycin.
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spelling pubmed-62596542018-12-07 Synthesis and Biological Evaluation of Novel Acenaphthene Derivatives as Potential Antitumor Agents Xie, Yong-Mei Deng, Yi Dai, Xiao-Yun Liu, Jie Ouyang, Liang Wei, Yu-Quan Zhao, Ying-Lan Molecules Article Twelve novel acenaphthene derivatives have been synthesized. The structures of all compounds were confirmed by (1)H-NMR, MS and elemental analysis. Their antitumor activities were evaluated in six human solid tumor cell lines, namely non-small cell lung cancer (H460), human colon adenocarcinoma (SW480), human breast cancer cell (MDA-MB-468 and SKRB-3), human melanoma cell (A375) and human pancreatic cancer (BxPC-3). Among them, compound 3c shows the best antitumor activity against SKRB-3 cell line, as high as the positive control adriamycin. MDPI 2011-03-17 /pmc/articles/PMC6259654/ /pubmed/21415833 http://dx.doi.org/10.3390/molecules16032519 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Xie, Yong-Mei
Deng, Yi
Dai, Xiao-Yun
Liu, Jie
Ouyang, Liang
Wei, Yu-Quan
Zhao, Ying-Lan
Synthesis and Biological Evaluation of Novel Acenaphthene Derivatives as Potential Antitumor Agents
title Synthesis and Biological Evaluation of Novel Acenaphthene Derivatives as Potential Antitumor Agents
title_full Synthesis and Biological Evaluation of Novel Acenaphthene Derivatives as Potential Antitumor Agents
title_fullStr Synthesis and Biological Evaluation of Novel Acenaphthene Derivatives as Potential Antitumor Agents
title_full_unstemmed Synthesis and Biological Evaluation of Novel Acenaphthene Derivatives as Potential Antitumor Agents
title_short Synthesis and Biological Evaluation of Novel Acenaphthene Derivatives as Potential Antitumor Agents
title_sort synthesis and biological evaluation of novel acenaphthene derivatives as potential antitumor agents
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259654/
https://www.ncbi.nlm.nih.gov/pubmed/21415833
http://dx.doi.org/10.3390/molecules16032519
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