Synthesis and Biological Evaluation of 4-Aroyl-6,7,8-Trimethoxyquinolines as a Novel Class of Anticancer Agents

A series of 2-aroyl and 2-aryl-5,6,7-trimethoxyquinoline and 4-aroyl-6,7,8-trimethoxyquinoline combretastatin analogs were synthesized and evaluated for their potential anticancer activity. The 4-aroylquinoline 11 inhibited the growth of the human cancer cells lines KB, HT-29, and MKN45, as well as...

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Autores principales: Hsieh, Cheng-Chih, Lee, Hsueh-Yun, Nien, Chih-Ying, Kuo, Ching-Chuan, Chang, Chi-Yen, Chang, Jang-Yang, Liou, Jing-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259658/
https://www.ncbi.nlm.nih.gov/pubmed/21383664
http://dx.doi.org/10.3390/molecules16032274
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author Hsieh, Cheng-Chih
Lee, Hsueh-Yun
Nien, Chih-Ying
Kuo, Ching-Chuan
Chang, Chi-Yen
Chang, Jang-Yang
Liou, Jing-Ping
author_facet Hsieh, Cheng-Chih
Lee, Hsueh-Yun
Nien, Chih-Ying
Kuo, Ching-Chuan
Chang, Chi-Yen
Chang, Jang-Yang
Liou, Jing-Ping
author_sort Hsieh, Cheng-Chih
collection PubMed
description A series of 2-aroyl and 2-aryl-5,6,7-trimethoxyquinoline and 4-aroyl-6,7,8-trimethoxyquinoline combretastatin analogs were synthesized and evaluated for their potential anticancer activity. The 4-aroylquinoline 11 inhibited the growth of the human cancer cells lines KB, HT-29, and MKN45, as well as the three human resistant cancer cell lines KB-vin10, KB-S15, and KB-7D, with IC(50) values of 217, 327, 239, 246, 213, and 252 nM, respectively.
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spelling pubmed-62596582018-12-07 Synthesis and Biological Evaluation of 4-Aroyl-6,7,8-Trimethoxyquinolines as a Novel Class of Anticancer Agents Hsieh, Cheng-Chih Lee, Hsueh-Yun Nien, Chih-Ying Kuo, Ching-Chuan Chang, Chi-Yen Chang, Jang-Yang Liou, Jing-Ping Molecules Article A series of 2-aroyl and 2-aryl-5,6,7-trimethoxyquinoline and 4-aroyl-6,7,8-trimethoxyquinoline combretastatin analogs were synthesized and evaluated for their potential anticancer activity. The 4-aroylquinoline 11 inhibited the growth of the human cancer cells lines KB, HT-29, and MKN45, as well as the three human resistant cancer cell lines KB-vin10, KB-S15, and KB-7D, with IC(50) values of 217, 327, 239, 246, 213, and 252 nM, respectively. MDPI 2011-03-07 /pmc/articles/PMC6259658/ /pubmed/21383664 http://dx.doi.org/10.3390/molecules16032274 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Hsieh, Cheng-Chih
Lee, Hsueh-Yun
Nien, Chih-Ying
Kuo, Ching-Chuan
Chang, Chi-Yen
Chang, Jang-Yang
Liou, Jing-Ping
Synthesis and Biological Evaluation of 4-Aroyl-6,7,8-Trimethoxyquinolines as a Novel Class of Anticancer Agents
title Synthesis and Biological Evaluation of 4-Aroyl-6,7,8-Trimethoxyquinolines as a Novel Class of Anticancer Agents
title_full Synthesis and Biological Evaluation of 4-Aroyl-6,7,8-Trimethoxyquinolines as a Novel Class of Anticancer Agents
title_fullStr Synthesis and Biological Evaluation of 4-Aroyl-6,7,8-Trimethoxyquinolines as a Novel Class of Anticancer Agents
title_full_unstemmed Synthesis and Biological Evaluation of 4-Aroyl-6,7,8-Trimethoxyquinolines as a Novel Class of Anticancer Agents
title_short Synthesis and Biological Evaluation of 4-Aroyl-6,7,8-Trimethoxyquinolines as a Novel Class of Anticancer Agents
title_sort synthesis and biological evaluation of 4-aroyl-6,7,8-trimethoxyquinolines as a novel class of anticancer agents
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259658/
https://www.ncbi.nlm.nih.gov/pubmed/21383664
http://dx.doi.org/10.3390/molecules16032274
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