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Antiplasmodial Natural Products
Malaria is a human infectious disease that is caused by four species of Plasmodium. It is responsible for more than 1 million deaths per year. Natural products contain a great variety of chemical structures and have been screened for antiplasmodial activity as potential sources of new antimalarial d...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259672/ http://dx.doi.org/10.3390/molecules16032146 |
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author | Nogueira, Cláudio R. Lopes, Lucia M. X. |
author_facet | Nogueira, Cláudio R. Lopes, Lucia M. X. |
author_sort | Nogueira, Cláudio R. |
collection | PubMed |
description | Malaria is a human infectious disease that is caused by four species of Plasmodium. It is responsible for more than 1 million deaths per year. Natural products contain a great variety of chemical structures and have been screened for antiplasmodial activity as potential sources of new antimalarial drugs. This review highlights studies on natural products with antimalarial and antiplasmodial activity reported in the literature from January 2009 to November 2010. A total of 360 antiplasmodial natural products comprised of terpenes, including iridoids, sesquiterpenes, diterpenes, terpenoid benzoquinones, steroids, quassinoids, limonoids, curcubitacins, and lanostanes; flavonoids; alkaloids; peptides; phenylalkanoids; xanthones; naphthopyrones; polyketides, including halenaquinones, peroxides, polyacetylenes, and resorcylic acids; depsidones; benzophenones; macrolides; and miscellaneous compounds, including halogenated compounds and chromenes are listed in this review. |
format | Online Article Text |
id | pubmed-6259672 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62596722018-12-07 Antiplasmodial Natural Products Nogueira, Cláudio R. Lopes, Lucia M. X. Molecules Review Malaria is a human infectious disease that is caused by four species of Plasmodium. It is responsible for more than 1 million deaths per year. Natural products contain a great variety of chemical structures and have been screened for antiplasmodial activity as potential sources of new antimalarial drugs. This review highlights studies on natural products with antimalarial and antiplasmodial activity reported in the literature from January 2009 to November 2010. A total of 360 antiplasmodial natural products comprised of terpenes, including iridoids, sesquiterpenes, diterpenes, terpenoid benzoquinones, steroids, quassinoids, limonoids, curcubitacins, and lanostanes; flavonoids; alkaloids; peptides; phenylalkanoids; xanthones; naphthopyrones; polyketides, including halenaquinones, peroxides, polyacetylenes, and resorcylic acids; depsidones; benzophenones; macrolides; and miscellaneous compounds, including halogenated compounds and chromenes are listed in this review. MDPI 2011-03-04 /pmc/articles/PMC6259672/ http://dx.doi.org/10.3390/molecules16032146 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Nogueira, Cláudio R. Lopes, Lucia M. X. Antiplasmodial Natural Products |
title | Antiplasmodial Natural Products |
title_full | Antiplasmodial Natural Products |
title_fullStr | Antiplasmodial Natural Products |
title_full_unstemmed | Antiplasmodial Natural Products |
title_short | Antiplasmodial Natural Products |
title_sort | antiplasmodial natural products |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259672/ http://dx.doi.org/10.3390/molecules16032146 |
work_keys_str_mv | AT nogueiraclaudior antiplasmodialnaturalproducts AT lopesluciamx antiplasmodialnaturalproducts |