Tin (IV) Chloride-Promoted One-Pot Synthesis of Novel Tacrine Analogues

A facile synthesis of potential acetylcholinesterase (AChE) inhibitors, the tacrine analogues 3a-p, has been accomplished by direct cyclocondensation of 1-aryl-4-cyano-5-aminopyrazole with β-ketoesters using tin(IV) chloride as catalyst. The structures of all the compounds have been confirmed by IR,...

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Detalles Bibliográficos
Autores principales: Hu, Huanan, Song, Liangfu, Fang, Qianqian, Zheng, Junjun, Meng, Zhiwei, Luo, Yiting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259742/
https://www.ncbi.nlm.nih.gov/pubmed/21343890
http://dx.doi.org/10.3390/molecules16021878
Descripción
Sumario:A facile synthesis of potential acetylcholinesterase (AChE) inhibitors, the tacrine analogues 3a-p, has been accomplished by direct cyclocondensation of 1-aryl-4-cyano-5-aminopyrazole with β-ketoesters using tin(IV) chloride as catalyst. The structures of all the compounds have been confirmed by IR, (1)H- and (13)C-NMR.

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