Tin (IV) Chloride-Promoted One-Pot Synthesis of Novel Tacrine Analogues

A facile synthesis of potential acetylcholinesterase (AChE) inhibitors, the tacrine analogues 3a-p, has been accomplished by direct cyclocondensation of 1-aryl-4-cyano-5-aminopyrazole with β-ketoesters using tin(IV) chloride as catalyst. The structures of all the compounds have been confirmed by IR,...

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Autores principales: Hu, Huanan, Song, Liangfu, Fang, Qianqian, Zheng, Junjun, Meng, Zhiwei, Luo, Yiting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259742/
https://www.ncbi.nlm.nih.gov/pubmed/21343890
http://dx.doi.org/10.3390/molecules16021878
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author Hu, Huanan
Song, Liangfu
Fang, Qianqian
Zheng, Junjun
Meng, Zhiwei
Luo, Yiting
author_facet Hu, Huanan
Song, Liangfu
Fang, Qianqian
Zheng, Junjun
Meng, Zhiwei
Luo, Yiting
author_sort Hu, Huanan
collection PubMed
description A facile synthesis of potential acetylcholinesterase (AChE) inhibitors, the tacrine analogues 3a-p, has been accomplished by direct cyclocondensation of 1-aryl-4-cyano-5-aminopyrazole with β-ketoesters using tin(IV) chloride as catalyst. The structures of all the compounds have been confirmed by IR, (1)H- and (13)C-NMR.
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spelling pubmed-62597422018-12-20 Tin (IV) Chloride-Promoted One-Pot Synthesis of Novel Tacrine Analogues Hu, Huanan Song, Liangfu Fang, Qianqian Zheng, Junjun Meng, Zhiwei Luo, Yiting Molecules Article A facile synthesis of potential acetylcholinesterase (AChE) inhibitors, the tacrine analogues 3a-p, has been accomplished by direct cyclocondensation of 1-aryl-4-cyano-5-aminopyrazole with β-ketoesters using tin(IV) chloride as catalyst. The structures of all the compounds have been confirmed by IR, (1)H- and (13)C-NMR. MDPI 2011-02-22 /pmc/articles/PMC6259742/ /pubmed/21343890 http://dx.doi.org/10.3390/molecules16021878 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Hu, Huanan
Song, Liangfu
Fang, Qianqian
Zheng, Junjun
Meng, Zhiwei
Luo, Yiting
Tin (IV) Chloride-Promoted One-Pot Synthesis of Novel Tacrine Analogues
title Tin (IV) Chloride-Promoted One-Pot Synthesis of Novel Tacrine Analogues
title_full Tin (IV) Chloride-Promoted One-Pot Synthesis of Novel Tacrine Analogues
title_fullStr Tin (IV) Chloride-Promoted One-Pot Synthesis of Novel Tacrine Analogues
title_full_unstemmed Tin (IV) Chloride-Promoted One-Pot Synthesis of Novel Tacrine Analogues
title_short Tin (IV) Chloride-Promoted One-Pot Synthesis of Novel Tacrine Analogues
title_sort tin (iv) chloride-promoted one-pot synthesis of novel tacrine analogues
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259742/
https://www.ncbi.nlm.nih.gov/pubmed/21343890
http://dx.doi.org/10.3390/molecules16021878
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AT fangqianqian tinivchloridepromotedonepotsynthesisofnoveltacrineanalogues
AT zhengjunjun tinivchloridepromotedonepotsynthesisofnoveltacrineanalogues
AT mengzhiwei tinivchloridepromotedonepotsynthesisofnoveltacrineanalogues
AT luoyiting tinivchloridepromotedonepotsynthesisofnoveltacrineanalogues

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