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Eukaryotic Voltage-Gated Sodium Channels: On Their Origins, Asymmetries, Losses, Diversification and Adaptations

The appearance of voltage-gated, sodium-selective channels with rapid gating kinetics was a limiting factor in the evolution of nervous systems. Two rounds of domain duplications generated a common 24 transmembrane segment (4 × 6 TM) template that is shared amongst voltage-gated sodium (Na(v)1 and N...

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Detalles Bibliográficos
Autores principales:	Fux, Julia E., Mehta, Amrit, Moffat, Jack, Spafford, J. David
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2018
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259924/ https://www.ncbi.nlm.nih.gov/pubmed/30519187 http://dx.doi.org/10.3389/fphys.2018.01406

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