Complement Factor H and Apolipoprotein E Participate in Regulation of Inflammation in THP-1 Macrophages

The alternative pathway (AP) of complement is constantly active in plasma and can easily be activated on self surfaces and trigger local inflammation. Host cells are protected from AP attack by Factor H (FH), the main AP regulator in plasma. Although complement is known to play a role in atheroscler...

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Detalles Bibliográficos
Autores principales: Nissilä, Eija, Hakala, Pipsa, Leskinen, Katarzyna, Roig, Angela, Syed, Shahan, Van Kessel, Kok P. M., Metso, Jari, De Haas, Carla J. C., Saavalainen, Päivi, Meri, Seppo, Chroni, Angeliki, Van Strijp, Jos A. G., Öörni, Katariina, Jauhiainen, Matti, Jokiranta, T. Sakari, Haapasalo, Karita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260146/
https://www.ncbi.nlm.nih.gov/pubmed/30519244
http://dx.doi.org/10.3389/fimmu.2018.02701

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