The Loss of ATRX Increases Susceptibility to Pancreatic Injury and Oncogenic KRAS in Female But Not Male Mice

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer death in North America, accounting for >30,000 deaths annually. Although somatic activating mutations in KRAS appear in 97% of PDAC patients, additional factors are required to initiate PDAC. Because mutation...

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Detalles Bibliográficos
Autores principales: Young, Claire C., Baker, Ryan M., Howlett, Christopher J., Hryciw, Todd, Herman, Joshua E., Higgs, Douglas, Gibbons, Richard, Crawford, Howard, Brown, Arthur, Pin, Christopher L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260375/
https://www.ncbi.nlm.nih.gov/pubmed/30510993
http://dx.doi.org/10.1016/j.jcmgh.2018.09.004

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