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Quantitative analysis of skeletal muscle by computed tomography imaging—State of the art

The radiological assessment of muscle properties—size, mass, density (also termed radiodensity), composition, and adipose tissue infiltration—is fundamental in muscle diseases. More recently, it also became obvious that muscle atrophy, also termed muscle wasting, is caused by or associated with many...

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Autores principales: Engelke, Klaus, Museyko, Oleg, Wang, Ling, Laredo, Jean-Denis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chinese Speaking Orthopaedic Society 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260391/
https://www.ncbi.nlm.nih.gov/pubmed/30533385
http://dx.doi.org/10.1016/j.jot.2018.10.004
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author Engelke, Klaus
Museyko, Oleg
Wang, Ling
Laredo, Jean-Denis
author_facet Engelke, Klaus
Museyko, Oleg
Wang, Ling
Laredo, Jean-Denis
author_sort Engelke, Klaus
collection PubMed
description The radiological assessment of muscle properties—size, mass, density (also termed radiodensity), composition, and adipose tissue infiltration—is fundamental in muscle diseases. More recently, it also became obvious that muscle atrophy, also termed muscle wasting, is caused by or associated with many other diseases or conditions, such as inactivity, malnutrition, chronic obstructive pulmonary disorder, cancer-associated cachexia, diabetes, renal and cardiac failure, and sarcopenia and even potentially with osteoporotic hip fracture. Several techniques have been developed to quantify muscle morphology and function. This review is dedicated to quantitative computed tomography (CT) of skeletal muscle and only includes a brief comparison with magnetic resonance imaging. Strengths and limitations of CT techniques are discussed in detail, including CT scanner calibration, acquisition and reconstruction protocols, and the various quantitative parameters that can be measured with CT, starting from simple volume measures to advanced parameters describing the adipose tissue distribution within muscle. Finally, the use of CT in sarcopenia and cachexia and the relevance of muscle parameters for the assessment of osteoporotic fracture illustrate the application of CT in two emerging areas of medical interest.
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spelling pubmed-62603912018-12-07 Quantitative analysis of skeletal muscle by computed tomography imaging—State of the art Engelke, Klaus Museyko, Oleg Wang, Ling Laredo, Jean-Denis J Orthop Translat Perspective The radiological assessment of muscle properties—size, mass, density (also termed radiodensity), composition, and adipose tissue infiltration—is fundamental in muscle diseases. More recently, it also became obvious that muscle atrophy, also termed muscle wasting, is caused by or associated with many other diseases or conditions, such as inactivity, malnutrition, chronic obstructive pulmonary disorder, cancer-associated cachexia, diabetes, renal and cardiac failure, and sarcopenia and even potentially with osteoporotic hip fracture. Several techniques have been developed to quantify muscle morphology and function. This review is dedicated to quantitative computed tomography (CT) of skeletal muscle and only includes a brief comparison with magnetic resonance imaging. Strengths and limitations of CT techniques are discussed in detail, including CT scanner calibration, acquisition and reconstruction protocols, and the various quantitative parameters that can be measured with CT, starting from simple volume measures to advanced parameters describing the adipose tissue distribution within muscle. Finally, the use of CT in sarcopenia and cachexia and the relevance of muscle parameters for the assessment of osteoporotic fracture illustrate the application of CT in two emerging areas of medical interest. Chinese Speaking Orthopaedic Society 2018-10-28 /pmc/articles/PMC6260391/ /pubmed/30533385 http://dx.doi.org/10.1016/j.jot.2018.10.004 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Perspective
Engelke, Klaus
Museyko, Oleg
Wang, Ling
Laredo, Jean-Denis
Quantitative analysis of skeletal muscle by computed tomography imaging—State of the art
title Quantitative analysis of skeletal muscle by computed tomography imaging—State of the art
title_full Quantitative analysis of skeletal muscle by computed tomography imaging—State of the art
title_fullStr Quantitative analysis of skeletal muscle by computed tomography imaging—State of the art
title_full_unstemmed Quantitative analysis of skeletal muscle by computed tomography imaging—State of the art
title_short Quantitative analysis of skeletal muscle by computed tomography imaging—State of the art
title_sort quantitative analysis of skeletal muscle by computed tomography imaging—state of the art
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260391/
https://www.ncbi.nlm.nih.gov/pubmed/30533385
http://dx.doi.org/10.1016/j.jot.2018.10.004
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