The rare translocation t(14;21)(q11;q22) detected in a Moroccan patient with T-cell acute lymphoblastic leukemia

Cytogenetic studies of acute lymphoblastic leukemia have been at the forefront of research in the pathogenesis of cancer. The presence of recurring chromosomal abnormalities (either numeral or structural rearrangements) provides immediate clues to the genetic events leading to leukemia and many abno...

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Autores principales: Chebihi, Z. Takki, Belkhayat, A., Chadli, E., Hessissen, L., El Khorassani, M., El Kababri, M., Kili, A., Khattab, M., Bakri, Y., Dakka, N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260455/
https://www.ncbi.nlm.nih.gov/pubmed/30533380
http://dx.doi.org/10.1016/j.lrr.2018.11.001
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author Chebihi, Z. Takki
Belkhayat, A.
Chadli, E.
Hessissen, L.
El Khorassani, M.
El Kababri, M.
Kili, A.
Khattab, M.
Bakri, Y.
Dakka, N.
author_facet Chebihi, Z. Takki
Belkhayat, A.
Chadli, E.
Hessissen, L.
El Khorassani, M.
El Kababri, M.
Kili, A.
Khattab, M.
Bakri, Y.
Dakka, N.
author_sort Chebihi, Z. Takki
collection PubMed
description Cytogenetic studies of acute lymphoblastic leukemia have been at the forefront of research in the pathogenesis of cancer. The presence of recurring chromosomal abnormalities (either numeral or structural rearrangements) provides immediate clues to the genetic events leading to leukemia and many abnormalities have important prognostic significance. The rare translocation t(14,21)(q11.2;q22) has been described in pediatric T lineage ALL in only one case so far in 2000. The present study is a case report of an ALL case in which we found a t(14,21)(q11.2;q22) as a non random chromosomal abnormality among 70 analyzed pediatric ALL cases referred exclusively to BIOLAB Laboratory from the children hospital of Morocco.
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spelling pubmed-62604552018-12-07 The rare translocation t(14;21)(q11;q22) detected in a Moroccan patient with T-cell acute lymphoblastic leukemia Chebihi, Z. Takki Belkhayat, A. Chadli, E. Hessissen, L. El Khorassani, M. El Kababri, M. Kili, A. Khattab, M. Bakri, Y. Dakka, N. Leuk Res Rep Article Cytogenetic studies of acute lymphoblastic leukemia have been at the forefront of research in the pathogenesis of cancer. The presence of recurring chromosomal abnormalities (either numeral or structural rearrangements) provides immediate clues to the genetic events leading to leukemia and many abnormalities have important prognostic significance. The rare translocation t(14,21)(q11.2;q22) has been described in pediatric T lineage ALL in only one case so far in 2000. The present study is a case report of an ALL case in which we found a t(14,21)(q11.2;q22) as a non random chromosomal abnormality among 70 analyzed pediatric ALL cases referred exclusively to BIOLAB Laboratory from the children hospital of Morocco. Elsevier 2018-11-22 /pmc/articles/PMC6260455/ /pubmed/30533380 http://dx.doi.org/10.1016/j.lrr.2018.11.001 Text en © 2018 The Authors. Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Chebihi, Z. Takki
Belkhayat, A.
Chadli, E.
Hessissen, L.
El Khorassani, M.
El Kababri, M.
Kili, A.
Khattab, M.
Bakri, Y.
Dakka, N.
The rare translocation t(14;21)(q11;q22) detected in a Moroccan patient with T-cell acute lymphoblastic leukemia
title The rare translocation t(14;21)(q11;q22) detected in a Moroccan patient with T-cell acute lymphoblastic leukemia
title_full The rare translocation t(14;21)(q11;q22) detected in a Moroccan patient with T-cell acute lymphoblastic leukemia
title_fullStr The rare translocation t(14;21)(q11;q22) detected in a Moroccan patient with T-cell acute lymphoblastic leukemia
title_full_unstemmed The rare translocation t(14;21)(q11;q22) detected in a Moroccan patient with T-cell acute lymphoblastic leukemia
title_short The rare translocation t(14;21)(q11;q22) detected in a Moroccan patient with T-cell acute lymphoblastic leukemia
title_sort rare translocation t(14;21)(q11;q22) detected in a moroccan patient with t-cell acute lymphoblastic leukemia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260455/
https://www.ncbi.nlm.nih.gov/pubmed/30533380
http://dx.doi.org/10.1016/j.lrr.2018.11.001
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