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Prevalence of Torsades de Pointes inducing drugs usage among elderly outpatients in North Jordan Hospitals
BACKGROUND: Torsade de Pointes (TdP) is an abnormal cardiac rhythm associated with a prolongation of QT interval. Although in most cases it spontaneously returns to the normal rhythm, TdP can lead to sudden cardiac death. Medications are the main cause of QT-prolongation and subsequent TdP flare, ev...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260490/ https://www.ncbi.nlm.nih.gov/pubmed/30532635 http://dx.doi.org/10.1016/j.jsps.2018.07.002 |
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author | Al-Azayzih, Ahmad Gharaibeh, Sara Jarab, Anan S. Mukattash, Tareq L. |
author_facet | Al-Azayzih, Ahmad Gharaibeh, Sara Jarab, Anan S. Mukattash, Tareq L. |
author_sort | Al-Azayzih, Ahmad |
collection | PubMed |
description | BACKGROUND: Torsade de Pointes (TdP) is an abnormal cardiac rhythm associated with a prolongation of QT interval. Although in most cases it spontaneously returns to the normal rhythm, TdP can lead to sudden cardiac death. Medications are the main cause of QT-prolongation and subsequent TdP flare, even though the exact mechanism of why some people evoke TdP but others do not is still unknown. It is evident that elderly patients are more susceptible to experience drug's side effects especially with chronically used medications. OBJECTIVES: To describe the pattern of prescribing drugs with risk of Torsade’s de Pointes among elderly patients who were visiting different outpatient clinics in North Jordan Hospitals. METHODS: All patients who were aged ≥65 years old and were visiting outpatient clinics in King Abdullah University Hospital (KAUH) and Princess Basma Hospital (PBH) through December 2016 were included in the study. A total of 5319 patients’ dispending records were collected and analyzed for the prevalence of drug-induced TdP using both Microsoft Excel and the SPSS statistical software. RESULTS: A total of 5319 patients were included in the study, more than half (58.5%, n = 3114) of patients were consuming drugs with risk of TdP. Almost half (49.4%, n = 1539) of these patients were women. The majority of patients (62.3%, n = 1939) were using only one drug with TdP risk. However, other patients were found to take five or six different TdP-inducing drugs. Excluding age and gender, 94.3% (n = 2937) of patients who were using TdP-inducing drugs had at least one additional risk factor of inducing TdP. CONCLUSION: High usage of TdP-inducing drugs among geriatric patients in North Jordan demonstrated the urgent need for increasing awareness of TdP’s risk induced by commonly prescribed medications. |
format | Online Article Text |
id | pubmed-6260490 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-62604902018-12-07 Prevalence of Torsades de Pointes inducing drugs usage among elderly outpatients in North Jordan Hospitals Al-Azayzih, Ahmad Gharaibeh, Sara Jarab, Anan S. Mukattash, Tareq L. Saudi Pharm J Article BACKGROUND: Torsade de Pointes (TdP) is an abnormal cardiac rhythm associated with a prolongation of QT interval. Although in most cases it spontaneously returns to the normal rhythm, TdP can lead to sudden cardiac death. Medications are the main cause of QT-prolongation and subsequent TdP flare, even though the exact mechanism of why some people evoke TdP but others do not is still unknown. It is evident that elderly patients are more susceptible to experience drug's side effects especially with chronically used medications. OBJECTIVES: To describe the pattern of prescribing drugs with risk of Torsade’s de Pointes among elderly patients who were visiting different outpatient clinics in North Jordan Hospitals. METHODS: All patients who were aged ≥65 years old and were visiting outpatient clinics in King Abdullah University Hospital (KAUH) and Princess Basma Hospital (PBH) through December 2016 were included in the study. A total of 5319 patients’ dispending records were collected and analyzed for the prevalence of drug-induced TdP using both Microsoft Excel and the SPSS statistical software. RESULTS: A total of 5319 patients were included in the study, more than half (58.5%, n = 3114) of patients were consuming drugs with risk of TdP. Almost half (49.4%, n = 1539) of these patients were women. The majority of patients (62.3%, n = 1939) were using only one drug with TdP risk. However, other patients were found to take five or six different TdP-inducing drugs. Excluding age and gender, 94.3% (n = 2937) of patients who were using TdP-inducing drugs had at least one additional risk factor of inducing TdP. CONCLUSION: High usage of TdP-inducing drugs among geriatric patients in North Jordan demonstrated the urgent need for increasing awareness of TdP’s risk induced by commonly prescribed medications. Elsevier 2018-12 2018-07-29 /pmc/articles/PMC6260490/ /pubmed/30532635 http://dx.doi.org/10.1016/j.jsps.2018.07.002 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Article Al-Azayzih, Ahmad Gharaibeh, Sara Jarab, Anan S. Mukattash, Tareq L. Prevalence of Torsades de Pointes inducing drugs usage among elderly outpatients in North Jordan Hospitals |
title | Prevalence of Torsades de Pointes inducing drugs usage among elderly outpatients in North Jordan Hospitals |
title_full | Prevalence of Torsades de Pointes inducing drugs usage among elderly outpatients in North Jordan Hospitals |
title_fullStr | Prevalence of Torsades de Pointes inducing drugs usage among elderly outpatients in North Jordan Hospitals |
title_full_unstemmed | Prevalence of Torsades de Pointes inducing drugs usage among elderly outpatients in North Jordan Hospitals |
title_short | Prevalence of Torsades de Pointes inducing drugs usage among elderly outpatients in North Jordan Hospitals |
title_sort | prevalence of torsades de pointes inducing drugs usage among elderly outpatients in north jordan hospitals |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260490/ https://www.ncbi.nlm.nih.gov/pubmed/30532635 http://dx.doi.org/10.1016/j.jsps.2018.07.002 |
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