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Patient-derived tumor immune microenvironments in patient-derived xenografts of lung cancer

BACKGROUND: Because patient-derived xenografts (PDXs) are grown in immunodeficient mouse strains, PDXs are regarded as lacking an immune microenvironment. However, whether patients’ immune cells co-exist in PDXs remains uncharacterized. METHODS: We cultured small pieces of lung PDX tissue in media c...

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Detalles Bibliográficos
Autores principales:	Pu, Xingxiang, Zhang, Ran, Wang, Li, Chen, Yungchang, Xu, Yi, Pataer, Apar, Meraz, Ismail M., Zhang, Xiaoshan, Wu, Shuhong, Wu, Lin, Su, Dan, Mao, Weimin, Heymach, John V., Roth, Jack A., Swisher, Stephen G., Fang, Bingliang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260563/ https://www.ncbi.nlm.nih.gov/pubmed/30477533 http://dx.doi.org/10.1186/s12967-018-1704-3

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