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Flavonoids modulate multidrug resistance through wnt signaling in P-glycoprotein overexpressing cell lines
BACKGROUND: Wnt signaling has been linked with P-glycoprotein (P-gp) overexpression and which was mainly mediated by β-catenin nuclear translocation. Flavonoids have already been reported as modulators of the Wnt/β-catenin pathway and hence they may serve as promising agents in the reversal of P-gp...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260573/ https://www.ncbi.nlm.nih.gov/pubmed/30477461 http://dx.doi.org/10.1186/s12885-018-5103-1 |