Three New Oblongolides from Phomopsis sp. XZ-01, an Endophytic Fungus from Camptotheca acuminate

Four new metabolites, including three new oblongolides named C1, P1, and X1 (1-3) and 6-hydroxyphomodiol (10), along with eight known compounds – oblongolides B (4), C (5), D (6), O (7), P (8) and U (9), (3R,4aR,5S,6R)-6-hydroxy-5-methylramulosin (11), and (3R)-5-methylmellein (12) – were isolated f...

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Autores principales: Lin, Ting, Wang, Guang Hui, Lin, Xiang, Hu, Zhi Yu, Chen, Quan Cheng, Xu, Yang, Zhang, Xiao Kun, Chen, Hai Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260605/
https://www.ncbi.nlm.nih.gov/pubmed/21512443
http://dx.doi.org/10.3390/molecules16043351
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author Lin, Ting
Wang, Guang Hui
Lin, Xiang
Hu, Zhi Yu
Chen, Quan Cheng
Xu, Yang
Zhang, Xiao Kun
Chen, Hai Feng
author_facet Lin, Ting
Wang, Guang Hui
Lin, Xiang
Hu, Zhi Yu
Chen, Quan Cheng
Xu, Yang
Zhang, Xiao Kun
Chen, Hai Feng
author_sort Lin, Ting
collection PubMed
description Four new metabolites, including three new oblongolides named C1, P1, and X1 (1-3) and 6-hydroxyphomodiol (10), along with eight known compounds – oblongolides B (4), C (5), D (6), O (7), P (8) and U (9), (3R,4aR,5S,6R)-6-hydroxy-5-methylramulosin (11), and (3R)-5-methylmellein (12) – were isolated from the endophytic fungal strain Phomopsis sp. XZ-01 of Camptotheca acuminate. Their structures were elucidated by spectroscopic analyses, including (1)H- and (13)C-NMR, 2D NMR (HSQC, HMBC, (1)H-(1)H COSY and NOESY) and HR-FT-MS. Cytotoxic activities of these compounds were evaluated. Some of them showed weak selective activities.
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spelling pubmed-62606052018-12-10 Three New Oblongolides from Phomopsis sp. XZ-01, an Endophytic Fungus from Camptotheca acuminate Lin, Ting Wang, Guang Hui Lin, Xiang Hu, Zhi Yu Chen, Quan Cheng Xu, Yang Zhang, Xiao Kun Chen, Hai Feng Molecules Article Four new metabolites, including three new oblongolides named C1, P1, and X1 (1-3) and 6-hydroxyphomodiol (10), along with eight known compounds – oblongolides B (4), C (5), D (6), O (7), P (8) and U (9), (3R,4aR,5S,6R)-6-hydroxy-5-methylramulosin (11), and (3R)-5-methylmellein (12) – were isolated from the endophytic fungal strain Phomopsis sp. XZ-01 of Camptotheca acuminate. Their structures were elucidated by spectroscopic analyses, including (1)H- and (13)C-NMR, 2D NMR (HSQC, HMBC, (1)H-(1)H COSY and NOESY) and HR-FT-MS. Cytotoxic activities of these compounds were evaluated. Some of them showed weak selective activities. MDPI 2011-04-19 /pmc/articles/PMC6260605/ /pubmed/21512443 http://dx.doi.org/10.3390/molecules16043351 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Lin, Ting
Wang, Guang Hui
Lin, Xiang
Hu, Zhi Yu
Chen, Quan Cheng
Xu, Yang
Zhang, Xiao Kun
Chen, Hai Feng
Three New Oblongolides from Phomopsis sp. XZ-01, an Endophytic Fungus from Camptotheca acuminate
title Three New Oblongolides from Phomopsis sp. XZ-01, an Endophytic Fungus from Camptotheca acuminate
title_full Three New Oblongolides from Phomopsis sp. XZ-01, an Endophytic Fungus from Camptotheca acuminate
title_fullStr Three New Oblongolides from Phomopsis sp. XZ-01, an Endophytic Fungus from Camptotheca acuminate
title_full_unstemmed Three New Oblongolides from Phomopsis sp. XZ-01, an Endophytic Fungus from Camptotheca acuminate
title_short Three New Oblongolides from Phomopsis sp. XZ-01, an Endophytic Fungus from Camptotheca acuminate
title_sort three new oblongolides from phomopsis sp. xz-01, an endophytic fungus from camptotheca acuminate
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260605/
https://www.ncbi.nlm.nih.gov/pubmed/21512443
http://dx.doi.org/10.3390/molecules16043351
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