On the Reducible Character of Haldane-Radić Enzyme Kinetics to Conventional and Logistic Michaelis-Menten Models

The conceptual and practical issues regarding the reduction of the Haldane-Radić enzymic mechanism, specific for cholinesterase kinetics, to the consecrated or logistically modified Michaelis-Menten kinetics, specific for some mutant enzymes, are here clarified as due to the limited initial substrat...

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Detalles Bibliográficos
Autor principal: Putz, Mihai V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260611/
https://www.ncbi.nlm.nih.gov/pubmed/21490560
http://dx.doi.org/10.3390/molecules16043128
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author Putz, Mihai V.
author_facet Putz, Mihai V.
author_sort Putz, Mihai V.
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description The conceptual and practical issues regarding the reduction of the Haldane-Radić enzymic mechanism, specific for cholinesterase kinetics, to the consecrated or logistically modified Michaelis-Menten kinetics, specific for some mutant enzymes, are here clarified as due to the limited initial substrate concentration, through detailed initial rate and progress curve analysis, even when other classical conditions for such equivalence are not entirely fulfilled.
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spelling pubmed-62606112018-12-10 On the Reducible Character of Haldane-Radić Enzyme Kinetics to Conventional and Logistic Michaelis-Menten Models Putz, Mihai V. Molecules Article The conceptual and practical issues regarding the reduction of the Haldane-Radić enzymic mechanism, specific for cholinesterase kinetics, to the consecrated or logistically modified Michaelis-Menten kinetics, specific for some mutant enzymes, are here clarified as due to the limited initial substrate concentration, through detailed initial rate and progress curve analysis, even when other classical conditions for such equivalence are not entirely fulfilled. MDPI 2011-04-13 /pmc/articles/PMC6260611/ /pubmed/21490560 http://dx.doi.org/10.3390/molecules16043128 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Putz, Mihai V.
On the Reducible Character of Haldane-Radić Enzyme Kinetics to Conventional and Logistic Michaelis-Menten Models
title On the Reducible Character of Haldane-Radić Enzyme Kinetics to Conventional and Logistic Michaelis-Menten Models
title_full On the Reducible Character of Haldane-Radić Enzyme Kinetics to Conventional and Logistic Michaelis-Menten Models
title_fullStr On the Reducible Character of Haldane-Radić Enzyme Kinetics to Conventional and Logistic Michaelis-Menten Models
title_full_unstemmed On the Reducible Character of Haldane-Radić Enzyme Kinetics to Conventional and Logistic Michaelis-Menten Models
title_short On the Reducible Character of Haldane-Radić Enzyme Kinetics to Conventional and Logistic Michaelis-Menten Models
title_sort on the reducible character of haldane-radić enzyme kinetics to conventional and logistic michaelis-menten models
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260611/
https://www.ncbi.nlm.nih.gov/pubmed/21490560
http://dx.doi.org/10.3390/molecules16043128
work_keys_str_mv AT putzmihaiv onthereduciblecharacterofhaldaneradicenzymekineticstoconventionalandlogisticmichaelismentenmodels

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