Salidroside Attenuates Hydrogen Peroxide-Induced Cell Damage Through a cAMP-Dependent Pathway

Salidroside, a major component of Rhodiola rosea L., has shown various pharmacological functions, including antioxidant effects, but the signal transduction pathway of its antioxidant effects is not very clear. In this study, we found that salidroside could attenuate hydrogen peroxide (H(2)O(2))-ind...

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Autores principales: Guan, Shuang, Wang, Wei, Lu, Jing, Qian, Wenhui, Huang, Guoren, Deng, Xuming, Wang, Xuelin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260613/
https://www.ncbi.nlm.nih.gov/pubmed/21512445
http://dx.doi.org/10.3390/molecules16043371
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author Guan, Shuang
Wang, Wei
Lu, Jing
Qian, Wenhui
Huang, Guoren
Deng, Xuming
Wang, Xuelin
author_facet Guan, Shuang
Wang, Wei
Lu, Jing
Qian, Wenhui
Huang, Guoren
Deng, Xuming
Wang, Xuelin
author_sort Guan, Shuang
collection PubMed
description Salidroside, a major component of Rhodiola rosea L., has shown various pharmacological functions, including antioxidant effects, but the signal transduction pathway of its antioxidant effects is not very clear. In this study, we found that salidroside could attenuate hydrogen peroxide (H(2)O(2))-induced HL-7702 cell damage, inhibit H(2)O(2)-induced cytosolic free Ca(2+) ([Ca(2+)]i) elevation, scavenge reactive oxygen species (ROS) and increase 3’-5’-cyclic adenosine monophosphate (cAMP) level in a dose-dependent manner, but it couldn’t influence 3’-5’-cyclic guanosine monophosphate (cGMP) levels. Therefore, these results indicated that the antioxidant effects of salidroside were associated with down-regulation of [Ca(2+)]i, ROS occur via a cAMP-dependent pathway.
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spelling pubmed-62606132018-12-10 Salidroside Attenuates Hydrogen Peroxide-Induced Cell Damage Through a cAMP-Dependent Pathway Guan, Shuang Wang, Wei Lu, Jing Qian, Wenhui Huang, Guoren Deng, Xuming Wang, Xuelin Molecules Article Salidroside, a major component of Rhodiola rosea L., has shown various pharmacological functions, including antioxidant effects, but the signal transduction pathway of its antioxidant effects is not very clear. In this study, we found that salidroside could attenuate hydrogen peroxide (H(2)O(2))-induced HL-7702 cell damage, inhibit H(2)O(2)-induced cytosolic free Ca(2+) ([Ca(2+)]i) elevation, scavenge reactive oxygen species (ROS) and increase 3’-5’-cyclic adenosine monophosphate (cAMP) level in a dose-dependent manner, but it couldn’t influence 3’-5’-cyclic guanosine monophosphate (cGMP) levels. Therefore, these results indicated that the antioxidant effects of salidroside were associated with down-regulation of [Ca(2+)]i, ROS occur via a cAMP-dependent pathway. MDPI 2011-04-19 /pmc/articles/PMC6260613/ /pubmed/21512445 http://dx.doi.org/10.3390/molecules16043371 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Guan, Shuang
Wang, Wei
Lu, Jing
Qian, Wenhui
Huang, Guoren
Deng, Xuming
Wang, Xuelin
Salidroside Attenuates Hydrogen Peroxide-Induced Cell Damage Through a cAMP-Dependent Pathway
title Salidroside Attenuates Hydrogen Peroxide-Induced Cell Damage Through a cAMP-Dependent Pathway
title_full Salidroside Attenuates Hydrogen Peroxide-Induced Cell Damage Through a cAMP-Dependent Pathway
title_fullStr Salidroside Attenuates Hydrogen Peroxide-Induced Cell Damage Through a cAMP-Dependent Pathway
title_full_unstemmed Salidroside Attenuates Hydrogen Peroxide-Induced Cell Damage Through a cAMP-Dependent Pathway
title_short Salidroside Attenuates Hydrogen Peroxide-Induced Cell Damage Through a cAMP-Dependent Pathway
title_sort salidroside attenuates hydrogen peroxide-induced cell damage through a camp-dependent pathway
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260613/
https://www.ncbi.nlm.nih.gov/pubmed/21512445
http://dx.doi.org/10.3390/molecules16043371
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