Structure Identification of Euphorbia Factor L3 and Its Induction of Apoptosis through the Mitochondrial Pathway

In this article, we have focused on the structure identification of Euphorbia factor L3 belonging to the lathyrane diterpenoids isolated from Caper Euphorbia Seed. Its anticancer activity in vitro against lung cancer A549 cells was also investigated and the IC(50) values were 34.04 ± 3.99 μM. Furthe...

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Detalles Bibliográficos
Autores principales: Zhang, Jian-Ye, Liang, Yong-Ju, Chen, Hu-Biao, Zheng, Li-Sheng, Mi, Yan-Jun, Wang, Fang, Zhao, Xiao-Qin, Wang, Xiao-Kun, Zhang, Hui, Fu, Li-Wu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260615/
https://www.ncbi.nlm.nih.gov/pubmed/21499222
http://dx.doi.org/10.3390/molecules16043222
Descripción
Sumario:In this article, we have focused on the structure identification of Euphorbia factor L3 belonging to the lathyrane diterpenoids isolated from Caper Euphorbia Seed. Its anticancer activity in vitro against lung cancer A549 cells was also investigated and the IC(50) values were 34.04 ± 3.99 μM. Furthermore, Euphorbia factor L3 could induce apoptosis in A549 cells via the mitochondrial pathway including loss of mitochondrial potential and release of cytochrome c.

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