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Structure Identification of Euphorbia Factor L3 and Its Induction of Apoptosis through the Mitochondrial Pathway
In this article, we have focused on the structure identification of Euphorbia factor L3 belonging to the lathyrane diterpenoids isolated from Caper Euphorbia Seed. Its anticancer activity in vitro against lung cancer A549 cells was also investigated and the IC(50) values were 34.04 ± 3.99 μM. Furthe...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260615/ https://www.ncbi.nlm.nih.gov/pubmed/21499222 http://dx.doi.org/10.3390/molecules16043222 |
| _version_ | 1783374831784296448 |
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| author | Zhang, Jian-Ye Liang, Yong-Ju Chen, Hu-Biao Zheng, Li-Sheng Mi, Yan-Jun Wang, Fang Zhao, Xiao-Qin Wang, Xiao-Kun Zhang, Hui Fu, Li-Wu |
| author_facet | Zhang, Jian-Ye Liang, Yong-Ju Chen, Hu-Biao Zheng, Li-Sheng Mi, Yan-Jun Wang, Fang Zhao, Xiao-Qin Wang, Xiao-Kun Zhang, Hui Fu, Li-Wu |
| author_sort | Zhang, Jian-Ye |
| collection | PubMed |
| description | In this article, we have focused on the structure identification of Euphorbia factor L3 belonging to the lathyrane diterpenoids isolated from Caper Euphorbia Seed. Its anticancer activity in vitro against lung cancer A549 cells was also investigated and the IC(50) values were 34.04 ± 3.99 μM. Furthermore, Euphorbia factor L3 could induce apoptosis in A549 cells via the mitochondrial pathway including loss of mitochondrial potential and release of cytochrome c. |
| format | Online Article Text |
| id | pubmed-6260615 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2011 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-62606152018-12-10 Structure Identification of Euphorbia Factor L3 and Its Induction of Apoptosis through the Mitochondrial Pathway Zhang, Jian-Ye Liang, Yong-Ju Chen, Hu-Biao Zheng, Li-Sheng Mi, Yan-Jun Wang, Fang Zhao, Xiao-Qin Wang, Xiao-Kun Zhang, Hui Fu, Li-Wu Molecules Article In this article, we have focused on the structure identification of Euphorbia factor L3 belonging to the lathyrane diterpenoids isolated from Caper Euphorbia Seed. Its anticancer activity in vitro against lung cancer A549 cells was also investigated and the IC(50) values were 34.04 ± 3.99 μM. Furthermore, Euphorbia factor L3 could induce apoptosis in A549 cells via the mitochondrial pathway including loss of mitochondrial potential and release of cytochrome c. MDPI 2011-04-15 /pmc/articles/PMC6260615/ /pubmed/21499222 http://dx.doi.org/10.3390/molecules16043222 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
| spellingShingle | Article Zhang, Jian-Ye Liang, Yong-Ju Chen, Hu-Biao Zheng, Li-Sheng Mi, Yan-Jun Wang, Fang Zhao, Xiao-Qin Wang, Xiao-Kun Zhang, Hui Fu, Li-Wu Structure Identification of Euphorbia Factor L3 and Its Induction of Apoptosis through the Mitochondrial Pathway |
| title | Structure Identification of Euphorbia Factor L3 and Its Induction of Apoptosis through the Mitochondrial Pathway |
| title_full | Structure Identification of Euphorbia Factor L3 and Its Induction of Apoptosis through the Mitochondrial Pathway |
| title_fullStr | Structure Identification of Euphorbia Factor L3 and Its Induction of Apoptosis through the Mitochondrial Pathway |
| title_full_unstemmed | Structure Identification of Euphorbia Factor L3 and Its Induction of Apoptosis through the Mitochondrial Pathway |
| title_short | Structure Identification of Euphorbia Factor L3 and Its Induction of Apoptosis through the Mitochondrial Pathway |
| title_sort | structure identification of euphorbia factor l3 and its induction of apoptosis through the mitochondrial pathway |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260615/ https://www.ncbi.nlm.nih.gov/pubmed/21499222 http://dx.doi.org/10.3390/molecules16043222 |
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