N-Cyanomethylnorboldine: A New Aporphine Isolated from Alseodaphne perakensis (Lauraceae)

A phytochemical study of the bark of Alseodaphne perakensis has yielded three aporphine alkaloids: the new compound N-cyanomethylnorboldine (1), and the two known alkaloids N-methyllaurotetanine (2) and norboldine (3). The isolation was achieved by chromatographic techniques and the structural eluci...

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Detalles Bibliográficos
Autores principales: Nafiah, Mohd Azlan, Mukhtar, Mat Ropi, Omar, Hanita, Ahmad, Kartini, Morita, Hiroshi, Litaudon, Marc, Awang, Khalijah, Hadi, A. Hamid A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260623/
https://www.ncbi.nlm.nih.gov/pubmed/21512448
http://dx.doi.org/10.3390/molecules16043402
Descripción
Sumario:A phytochemical study of the bark of Alseodaphne perakensis has yielded three aporphine alkaloids: the new compound N-cyanomethylnorboldine (1), and the two known alkaloids N-methyllaurotetanine (2) and norboldine (3). The isolation was achieved by chromatographic techniques and the structural elucidation was performed via spectral methods, notably 1D- and 2D-NMR, UV, IR, and HRFABMS. The vasorelaxation activity of compound 1 has been studied.

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