N-Cyanomethylnorboldine: A New Aporphine Isolated from Alseodaphne perakensis (Lauraceae)

A phytochemical study of the bark of Alseodaphne perakensis has yielded three aporphine alkaloids: the new compound N-cyanomethylnorboldine (1), and the two known alkaloids N-methyllaurotetanine (2) and norboldine (3). The isolation was achieved by chromatographic techniques and the structural eluci...

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Autores principales: Nafiah, Mohd Azlan, Mukhtar, Mat Ropi, Omar, Hanita, Ahmad, Kartini, Morita, Hiroshi, Litaudon, Marc, Awang, Khalijah, Hadi, A. Hamid A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260623/
https://www.ncbi.nlm.nih.gov/pubmed/21512448
http://dx.doi.org/10.3390/molecules16043402
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author Nafiah, Mohd Azlan
Mukhtar, Mat Ropi
Omar, Hanita
Ahmad, Kartini
Morita, Hiroshi
Litaudon, Marc
Awang, Khalijah
Hadi, A. Hamid A.
author_facet Nafiah, Mohd Azlan
Mukhtar, Mat Ropi
Omar, Hanita
Ahmad, Kartini
Morita, Hiroshi
Litaudon, Marc
Awang, Khalijah
Hadi, A. Hamid A.
author_sort Nafiah, Mohd Azlan
collection PubMed
description A phytochemical study of the bark of Alseodaphne perakensis has yielded three aporphine alkaloids: the new compound N-cyanomethylnorboldine (1), and the two known alkaloids N-methyllaurotetanine (2) and norboldine (3). The isolation was achieved by chromatographic techniques and the structural elucidation was performed via spectral methods, notably 1D- and 2D-NMR, UV, IR, and HRFABMS. The vasorelaxation activity of compound 1 has been studied.
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spelling pubmed-62606232018-12-10 N-Cyanomethylnorboldine: A New Aporphine Isolated from Alseodaphne perakensis (Lauraceae) Nafiah, Mohd Azlan Mukhtar, Mat Ropi Omar, Hanita Ahmad, Kartini Morita, Hiroshi Litaudon, Marc Awang, Khalijah Hadi, A. Hamid A. Molecules Article A phytochemical study of the bark of Alseodaphne perakensis has yielded three aporphine alkaloids: the new compound N-cyanomethylnorboldine (1), and the two known alkaloids N-methyllaurotetanine (2) and norboldine (3). The isolation was achieved by chromatographic techniques and the structural elucidation was performed via spectral methods, notably 1D- and 2D-NMR, UV, IR, and HRFABMS. The vasorelaxation activity of compound 1 has been studied. MDPI 2011-04-20 /pmc/articles/PMC6260623/ /pubmed/21512448 http://dx.doi.org/10.3390/molecules16043402 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Nafiah, Mohd Azlan
Mukhtar, Mat Ropi
Omar, Hanita
Ahmad, Kartini
Morita, Hiroshi
Litaudon, Marc
Awang, Khalijah
Hadi, A. Hamid A.
N-Cyanomethylnorboldine: A New Aporphine Isolated from Alseodaphne perakensis (Lauraceae)
title N-Cyanomethylnorboldine: A New Aporphine Isolated from Alseodaphne perakensis (Lauraceae)
title_full N-Cyanomethylnorboldine: A New Aporphine Isolated from Alseodaphne perakensis (Lauraceae)
title_fullStr N-Cyanomethylnorboldine: A New Aporphine Isolated from Alseodaphne perakensis (Lauraceae)
title_full_unstemmed N-Cyanomethylnorboldine: A New Aporphine Isolated from Alseodaphne perakensis (Lauraceae)
title_short N-Cyanomethylnorboldine: A New Aporphine Isolated from Alseodaphne perakensis (Lauraceae)
title_sort n-cyanomethylnorboldine: a new aporphine isolated from alseodaphne perakensis (lauraceae)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260623/
https://www.ncbi.nlm.nih.gov/pubmed/21512448
http://dx.doi.org/10.3390/molecules16043402
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