Antioxidant, Total Phenolic Content and Cytotoxicity Evaluation of Selected Malaysian Plants

Aqueous and ethanol extracts of different traditional Malaysian plants (Polygonum minus, Andrographis paniculata, Curcuma xanthorrhiza, Momordica charantia and Strobilanthes crispus) were evaluated for their antioxidant properties, total phenolic content and cytotoxic activity. Antioxidant activity...

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Autores principales: Qader, Suhailah Wasman, Abdulla, Mahmood Ameen, Chua, Lee Suan, Najim, Nigar, Zain, Mazatulikhma Mat, Hamdan, Salehhuddin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260633/
https://www.ncbi.nlm.nih.gov/pubmed/21512451
http://dx.doi.org/10.3390/molecules16043433
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author Qader, Suhailah Wasman
Abdulla, Mahmood Ameen
Chua, Lee Suan
Najim, Nigar
Zain, Mazatulikhma Mat
Hamdan, Salehhuddin
author_facet Qader, Suhailah Wasman
Abdulla, Mahmood Ameen
Chua, Lee Suan
Najim, Nigar
Zain, Mazatulikhma Mat
Hamdan, Salehhuddin
author_sort Qader, Suhailah Wasman
collection PubMed
description Aqueous and ethanol extracts of different traditional Malaysian plants (Polygonum minus, Andrographis paniculata, Curcuma xanthorrhiza, Momordica charantia and Strobilanthes crispus) were evaluated for their antioxidant properties, total phenolic content and cytotoxic activity. Antioxidant activity was evaluated by using 1,1-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assays. The results showed that ethanol extracts contain high antioxidant activities compared to aqueous extracts. The findings exhibited a strong correlation between antioxidant activity and the total phenol contents. In addition, all the plant extracts showed non-toxic effects against a normal human lung fibroblast cell line (Hs888Lu). Although traditionally aqueous extracts are used, we determined that ethanol extracts usually achieved better activity in the assays.
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spelling pubmed-62606332018-12-10 Antioxidant, Total Phenolic Content and Cytotoxicity Evaluation of Selected Malaysian Plants Qader, Suhailah Wasman Abdulla, Mahmood Ameen Chua, Lee Suan Najim, Nigar Zain, Mazatulikhma Mat Hamdan, Salehhuddin Molecules Article Aqueous and ethanol extracts of different traditional Malaysian plants (Polygonum minus, Andrographis paniculata, Curcuma xanthorrhiza, Momordica charantia and Strobilanthes crispus) were evaluated for their antioxidant properties, total phenolic content and cytotoxic activity. Antioxidant activity was evaluated by using 1,1-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assays. The results showed that ethanol extracts contain high antioxidant activities compared to aqueous extracts. The findings exhibited a strong correlation between antioxidant activity and the total phenol contents. In addition, all the plant extracts showed non-toxic effects against a normal human lung fibroblast cell line (Hs888Lu). Although traditionally aqueous extracts are used, we determined that ethanol extracts usually achieved better activity in the assays. MDPI 2011-04-21 /pmc/articles/PMC6260633/ /pubmed/21512451 http://dx.doi.org/10.3390/molecules16043433 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Qader, Suhailah Wasman
Abdulla, Mahmood Ameen
Chua, Lee Suan
Najim, Nigar
Zain, Mazatulikhma Mat
Hamdan, Salehhuddin
Antioxidant, Total Phenolic Content and Cytotoxicity Evaluation of Selected Malaysian Plants
title Antioxidant, Total Phenolic Content and Cytotoxicity Evaluation of Selected Malaysian Plants
title_full Antioxidant, Total Phenolic Content and Cytotoxicity Evaluation of Selected Malaysian Plants
title_fullStr Antioxidant, Total Phenolic Content and Cytotoxicity Evaluation of Selected Malaysian Plants
title_full_unstemmed Antioxidant, Total Phenolic Content and Cytotoxicity Evaluation of Selected Malaysian Plants
title_short Antioxidant, Total Phenolic Content and Cytotoxicity Evaluation of Selected Malaysian Plants
title_sort antioxidant, total phenolic content and cytotoxicity evaluation of selected malaysian plants
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260633/
https://www.ncbi.nlm.nih.gov/pubmed/21512451
http://dx.doi.org/10.3390/molecules16043433
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