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A New Abietene Diterpene and Other Constituents from Kaempferia angustifolia Rosc.
A new abietene diterpene, kaempfolienol (5S,6S,7S,9S,10S,11R,13S-abiet-8(14)-enepenta-6,7,9,11,13-ol, 1), was isolated from a rhizome extract of Kaempferia angustifolia Rosc. along with the known compounds crotepoxide, boesenboxide, zeylenol, 2′-hydroxy-4,4′,6′-trimethoxychalcone, (24S)-24-methyl-5α...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260639/ https://www.ncbi.nlm.nih.gov/pubmed/21475124 http://dx.doi.org/10.3390/molecules16043018 |
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author | Tang, Sook Wah Sukari, Mohd Aspollah Rahmani, Mawardi Lajis, Nordin Hj. Ali, Abdul Manaf |
author_facet | Tang, Sook Wah Sukari, Mohd Aspollah Rahmani, Mawardi Lajis, Nordin Hj. Ali, Abdul Manaf |
author_sort | Tang, Sook Wah |
collection | PubMed |
description | A new abietene diterpene, kaempfolienol (5S,6S,7S,9S,10S,11R,13S-abiet-8(14)-enepenta-6,7,9,11,13-ol, 1), was isolated from a rhizome extract of Kaempferia angustifolia Rosc. along with the known compounds crotepoxide, boesenboxide, zeylenol, 2′-hydroxy-4,4′,6′-trimethoxychalcone, (24S)-24-methyl-5α-lanosta-9(11),25-dien-3β-ol, β-sitosterol and β-sitosterol-3-O-β-D-glucopyranoside. The structures of all compounds were elucidated on the basis of mass spectroscopic and NMR data. Zeylenol (2), the major constituent of the plant, was derivatized into diacetate, triacetate and epoxide derivatives through standard organic reactions. The cytotoxic activity of compounds 1, 2 and the zeylenol derivatives was evaluated against the HL-60, MCF-7, HT-29 and HeLa cell lines. |
format | Online Article Text |
id | pubmed-6260639 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-62606392018-12-10 A New Abietene Diterpene and Other Constituents from Kaempferia angustifolia Rosc. Tang, Sook Wah Sukari, Mohd Aspollah Rahmani, Mawardi Lajis, Nordin Hj. Ali, Abdul Manaf Molecules Article A new abietene diterpene, kaempfolienol (5S,6S,7S,9S,10S,11R,13S-abiet-8(14)-enepenta-6,7,9,11,13-ol, 1), was isolated from a rhizome extract of Kaempferia angustifolia Rosc. along with the known compounds crotepoxide, boesenboxide, zeylenol, 2′-hydroxy-4,4′,6′-trimethoxychalcone, (24S)-24-methyl-5α-lanosta-9(11),25-dien-3β-ol, β-sitosterol and β-sitosterol-3-O-β-D-glucopyranoside. The structures of all compounds were elucidated on the basis of mass spectroscopic and NMR data. Zeylenol (2), the major constituent of the plant, was derivatized into diacetate, triacetate and epoxide derivatives through standard organic reactions. The cytotoxic activity of compounds 1, 2 and the zeylenol derivatives was evaluated against the HL-60, MCF-7, HT-29 and HeLa cell lines. MDPI 2011-04-07 /pmc/articles/PMC6260639/ /pubmed/21475124 http://dx.doi.org/10.3390/molecules16043018 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Article Tang, Sook Wah Sukari, Mohd Aspollah Rahmani, Mawardi Lajis, Nordin Hj. Ali, Abdul Manaf A New Abietene Diterpene and Other Constituents from Kaempferia angustifolia Rosc. |
title | A New Abietene Diterpene and Other Constituents from Kaempferia angustifolia Rosc. |
title_full | A New Abietene Diterpene and Other Constituents from Kaempferia angustifolia Rosc. |
title_fullStr | A New Abietene Diterpene and Other Constituents from Kaempferia angustifolia Rosc. |
title_full_unstemmed | A New Abietene Diterpene and Other Constituents from Kaempferia angustifolia Rosc. |
title_short | A New Abietene Diterpene and Other Constituents from Kaempferia angustifolia Rosc. |
title_sort | new abietene diterpene and other constituents from kaempferia angustifolia rosc. |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260639/ https://www.ncbi.nlm.nih.gov/pubmed/21475124 http://dx.doi.org/10.3390/molecules16043018 |
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