Screening for Compounds with Aromatase Inhibiting Activities from Atractylodes macrocephala Koidz

Ten compounds were isolated from the dichloromethane extract of Atractylodes macrocephala and their aromatase inhibiting activities were tested using an in vitro fluorescent-based aromatase assay. The results indicated that atractylenolide I (1), atractylenolide II (2) and atractylenolide III (3) ha...

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Detalles Bibliográficos
Autores principales: Jiang, Hai, Shi, Jing, Li, Yuanyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260643/
https://www.ncbi.nlm.nih.gov/pubmed/21494203
http://dx.doi.org/10.3390/molecules16043146
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author Jiang, Hai
Shi, Jing
Li, Yuanyuan
author_facet Jiang, Hai
Shi, Jing
Li, Yuanyuan
author_sort Jiang, Hai
collection PubMed
description Ten compounds were isolated from the dichloromethane extract of Atractylodes macrocephala and their aromatase inhibiting activities were tested using an in vitro fluorescent-based aromatase assay. The results indicated that atractylenolide I (1), atractylenolide II (2) and atractylenolide III (3) had inhibition ratios of 94.56 ± 0.70%, 90.93 ± 1.41% and 86.31 ± 8.46%, respectively, at a concentration of 10 μM. We conclude from our results that atractylenolide and its derivates may serve as potential aromatase inhibitors (AIs) and thus merit continued study in the future.
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spelling pubmed-62606432018-12-10 Screening for Compounds with Aromatase Inhibiting Activities from Atractylodes macrocephala Koidz Jiang, Hai Shi, Jing Li, Yuanyuan Molecules Communication Ten compounds were isolated from the dichloromethane extract of Atractylodes macrocephala and their aromatase inhibiting activities were tested using an in vitro fluorescent-based aromatase assay. The results indicated that atractylenolide I (1), atractylenolide II (2) and atractylenolide III (3) had inhibition ratios of 94.56 ± 0.70%, 90.93 ± 1.41% and 86.31 ± 8.46%, respectively, at a concentration of 10 μM. We conclude from our results that atractylenolide and its derivates may serve as potential aromatase inhibitors (AIs) and thus merit continued study in the future. MDPI 2011-04-14 /pmc/articles/PMC6260643/ /pubmed/21494203 http://dx.doi.org/10.3390/molecules16043146 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Communication
Jiang, Hai
Shi, Jing
Li, Yuanyuan
Screening for Compounds with Aromatase Inhibiting Activities from Atractylodes macrocephala Koidz
title Screening for Compounds with Aromatase Inhibiting Activities from Atractylodes macrocephala Koidz
title_full Screening for Compounds with Aromatase Inhibiting Activities from Atractylodes macrocephala Koidz
title_fullStr Screening for Compounds with Aromatase Inhibiting Activities from Atractylodes macrocephala Koidz
title_full_unstemmed Screening for Compounds with Aromatase Inhibiting Activities from Atractylodes macrocephala Koidz
title_short Screening for Compounds with Aromatase Inhibiting Activities from Atractylodes macrocephala Koidz
title_sort screening for compounds with aromatase inhibiting activities from atractylodes macrocephala koidz
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260643/
https://www.ncbi.nlm.nih.gov/pubmed/21494203
http://dx.doi.org/10.3390/molecules16043146
work_keys_str_mv AT jianghai screeningforcompoundswitharomataseinhibitingactivitiesfromatractylodesmacrocephalakoidz
AT shijing screeningforcompoundswitharomataseinhibitingactivitiesfromatractylodesmacrocephalakoidz
AT liyuanyuan screeningforcompoundswitharomataseinhibitingactivitiesfromatractylodesmacrocephalakoidz

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