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dbMPIKT: a database of kinetic and thermodynamic mutant protein interactions

BACKGROUND: Protein-protein interactions (PPIs) play important roles in biological functions. Studies of the effects of mutants on protein interactions can provide further understanding of PPIs. Currently, many databases collect experimental mutants to assess protein interactions, but most of these...

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Detalles Bibliográficos
Autores principales: Liu, Quanya, Chen, Peng, Wang, Bing, Zhang, Jun, Li, Jinyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260753/
https://www.ncbi.nlm.nih.gov/pubmed/30482172
http://dx.doi.org/10.1186/s12859-018-2493-7
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author Liu, Quanya
Chen, Peng
Wang, Bing
Zhang, Jun
Li, Jinyan
author_facet Liu, Quanya
Chen, Peng
Wang, Bing
Zhang, Jun
Li, Jinyan
author_sort Liu, Quanya
collection PubMed
description BACKGROUND: Protein-protein interactions (PPIs) play important roles in biological functions. Studies of the effects of mutants on protein interactions can provide further understanding of PPIs. Currently, many databases collect experimental mutants to assess protein interactions, but most of these databases are old and have not been updated for several years. RESULTS: To address this issue, we manually curated a kinetic and thermodynamic database of mutant protein interactions (dbMPIKT) that is freely accessible at our website. This database contains 5291 mutants in protein interactions collected from previous databases and the literature published within the last three years. Furthermore, some data analysis, such as mutation number, mutation type, protein pair source and network map construction, can be performed online. CONCLUSION: Our work can promote the study on PPIs, and novel information can be mined from the new database. Our database is available in http://DeepLearner.ahu.edu.cn/web/dbMPIKT/ for use by all, including both academics and non-academics. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12859-018-2493-7) contains supplementary material, which is available to authorized users.
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spelling pubmed-62607532018-12-10 dbMPIKT: a database of kinetic and thermodynamic mutant protein interactions Liu, Quanya Chen, Peng Wang, Bing Zhang, Jun Li, Jinyan BMC Bioinformatics Database BACKGROUND: Protein-protein interactions (PPIs) play important roles in biological functions. Studies of the effects of mutants on protein interactions can provide further understanding of PPIs. Currently, many databases collect experimental mutants to assess protein interactions, but most of these databases are old and have not been updated for several years. RESULTS: To address this issue, we manually curated a kinetic and thermodynamic database of mutant protein interactions (dbMPIKT) that is freely accessible at our website. This database contains 5291 mutants in protein interactions collected from previous databases and the literature published within the last three years. Furthermore, some data analysis, such as mutation number, mutation type, protein pair source and network map construction, can be performed online. CONCLUSION: Our work can promote the study on PPIs, and novel information can be mined from the new database. Our database is available in http://DeepLearner.ahu.edu.cn/web/dbMPIKT/ for use by all, including both academics and non-academics. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12859-018-2493-7) contains supplementary material, which is available to authorized users. BioMed Central 2018-11-27 /pmc/articles/PMC6260753/ /pubmed/30482172 http://dx.doi.org/10.1186/s12859-018-2493-7 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Database
Liu, Quanya
Chen, Peng
Wang, Bing
Zhang, Jun
Li, Jinyan
dbMPIKT: a database of kinetic and thermodynamic mutant protein interactions
title dbMPIKT: a database of kinetic and thermodynamic mutant protein interactions
title_full dbMPIKT: a database of kinetic and thermodynamic mutant protein interactions
title_fullStr dbMPIKT: a database of kinetic and thermodynamic mutant protein interactions
title_full_unstemmed dbMPIKT: a database of kinetic and thermodynamic mutant protein interactions
title_short dbMPIKT: a database of kinetic and thermodynamic mutant protein interactions
title_sort dbmpikt: a database of kinetic and thermodynamic mutant protein interactions
topic Database
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260753/
https://www.ncbi.nlm.nih.gov/pubmed/30482172
http://dx.doi.org/10.1186/s12859-018-2493-7
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