Cargando…

Distinct expression profiles and functions of Kindlins in breast cancer

BACKGROUND: Kindlin-1, − 2, and − 3 are the three members of the Kindlin family. They are best known as regulators of integrin functions, contributing to fundamental biological processes such as cell survival, adhesion and migration. Their deregulation leads to diverse pathologies including a broad...

Descripción completa

Detalles Bibliográficos
Autores principales:	Azorin, Paula, Bonin, Florian, Moukachar, Ahmad, Ponceau, Aurélie, Vacher, Sophie, Bièche, Ivan, Marangoni, Elisabetta, Fuhrmann, Laetitia, Vincent-Salomon, Anne, Lidereau, Rosette, Driouch, Keltouma
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260766/ https://www.ncbi.nlm.nih.gov/pubmed/30477537 http://dx.doi.org/10.1186/s13046-018-0955-4

Ejemplares similares

Kindlin‐1 drives early steps of breast cancer metastasis
por: Bonin, Florian, et al.
Publicado: (2022)

Kindlin‐1 modulates the EGFR pathway and predicts sensitivity to EGFR inhibitors across cancer types
por: Azorin, Paula, et al.
Publicado: (2022)

VOPP1 promotes breast tumorigenesis by interacting with the tumor suppressor WWOX
por: Bonin, Florian, et al.
Publicado: (2018)

PIK3CA mutation impact on survival in breast cancer patients and in ERα, PR and ERBB2-based subgroups
por: Cizkova, Magdalena, et al.
Publicado: (2012)

Molecular Functions of WWOX Potentially Involved in Cancer Development
por: Taouis, Karim, et al.
Publicado: (2021)

Expression analysis of mitotic spindle checkpoint genes in breast carcinoma: role of NDC80/HEC1 in early breast tumorigenicity, and a two-gene signature for aneuploidy
por: Bièche, Ivan, et al.
Publicado: (2011)

WWOX binds MERIT40 and modulates its function in homologous recombination, implications in breast cancer
por: Taouis, Karim, et al.
Publicado: (2023)

The high protein expression of FOXO3, but not that of FOXO1, is associated with markers of good prognosis
por: Lallemand, François, et al.
Publicado: (2020)

Gene Expression Profiling Reveals New Aspects of PIK3CA Mutation in ERalpha-Positive Breast Cancer: Major Implication of the Wnt Signaling Pathway
por: Cizkova, Magdalena, et al.
Publicado: (2010)

MiR-190b, the highest up-regulated miRNA in ERα-positive compared to ERα-negative breast tumors, a new biomarker in breast cancers?
por: Cizeron-Clairac, Geraldine, et al.
Publicado: (2015)

NF-kappa B genes have a major role in Inflammatory Breast Cancer
por: Lerebours, Florence, et al.
Publicado: (2008)

EHD2 is a Predictive Biomarker of Chemotherapy Efficacy in Triple Negative Breast Carcinoma
por: Shen, Wei-Wei, et al.
Publicado: (2020)

Update on inflammatory breast cancer
por: Lerebours, Florence, et al.
Publicado: (2005)

PIK3R1 underexpression is an independent prognostic marker in breast cancer
por: Cizkova, Magdalena, et al.
Publicado: (2013)

Identification of a three-gene expression signature of poor-prognosis breast carcinoma
por: Bièche, Ivan, et al.
Publicado: (2004)

Molecular features of untreated breast cancer and initial metastatic event inform clinical decision-making and predict outcome: long-term results of ESOPE, a single-arm prospective multicenter study
por: Callens, Céline, et al.
Publicado: (2021)

Relationship between intratumoral expression of genes coding for xenobiotic-metabolizing enzymes and benefit from adjuvant tamoxifen in estrogen receptor alpha-positive postmenopausal breast carcinoma
por: Bièche, Ivan, et al.
Publicado: (2004)

Similar NF-κB Gene Signatures in TNF-α Treated Human Endothelial Cells and Breast Tumor Biopsies
por: Perrot-Applanat, Martine, et al.
Publicado: (2011)

ERBB2 mutations associated with solid variant of high-grade invasive lobular breast carcinomas
por: Deniziaut, Gabrielle, et al.
Publicado: (2016)

Oxidative phosphorylation is a metabolic vulnerability of endocrine therapy and palbociclib resistant metastatic breast cancers
por: El-Botty, Rania, et al.
Publicado: (2023)

HORMAD1 overexpression predicts response to anthracycline–cyclophosphamide and survival in triple‐negative breast cancers
por: El‐Botty, Rania, et al.
Publicado: (2023)

Prognostic value of maspin mRNA expression in ERα-positive postmenopausal breast carcinomas
por: Bièche, I, et al.
Publicado: (2003)

A Molecular Predictor Reassesses Classification of Human Grade II/III Gliomas
por: Rème, Thierry, et al.
Publicado: (2013)

Prognostic value of a newly identified MALAT1 alternatively spliced transcript in breast cancer
por: Meseure, Didier, et al.
Publicado: (2016)

Molecular analyses of human breast cancer metastasis: genetic markers of progression
por: Driouch, K, et al.
Publicado: (2000)

Involvement of the FOXO6 transcriptional factor in breast carcinogenesis
por: Lallemand, François, et al.
Publicado: (2017)

Of Kindlins and Cancer
por: Plow, Edward F., et al.
Publicado: (2016)

Opposite Role of Kindlin-1 and Kindlin-2 in Lung Cancers
por: Zhan, Jun, et al.
Publicado: (2012)

Response to mTOR and PI3K inhibitors in enzalutamide-resistant luminal androgen receptor triple-negative breast cancer patient-derived xenografts
por: Coussy, Florence, et al.
Publicado: (2020)

GIV•Kindlin Interaction Is Required for Kindlin-Mediated Integrin Recognition and Activation
por: Rohena, Cristina, et al.
Publicado: (2020)

Combination of COX-2 expression and PIK3CA mutation as prognostic and predictive markers for celecoxib treatment in breast cancer
por: Tury, Sandrine, et al.
Publicado: (2016)

Phylogenetic Analysis of Kindlins Suggests Subfunctionalization of an Ancestral Unduplicated Kindlin into Three Paralogs in Vertebrates
por: Khan, Ammad Aslam, et al.
Publicado: (2011)

HRAS is a therapeutic target in malignant chemo-resistant adenomyoepithelioma of the breast
por: Bièche, Ivan, et al.
Publicado: (2021)

Kindlin-2 Mediates Mechanical Activation of Cardiac Myofibroblasts
por: Godbout, Elena, et al.
Publicado: (2020)

Predictive Gene Signature of Response to the Anti-TweakR mAb PDL192 in Patient-Derived Breast Cancer Xenografts
por: de Plater, Ludmilla, et al.
Publicado: (2014)

Hedgehog pathway activation in human transitional cell carcinoma of the bladder
por: Pignot, G, et al.
Publicado: (2012)

PKD1 is a potential biomarker and therapeutic target in triple-negative breast cancer
por: Spasojevic, Caroline, et al.
Publicado: (2018)

Inhibition of mTOR downregulates expression of DNA repair proteins and is highly efficient against BRCA2-mutated breast cancer in combination to PARP inhibition
por: El Botty, Rania, et al.
Publicado: (2018)

ATM has a major role in the double-strand break repair pathway dysregulation in sporadic breast carcinomas and is an independent prognostic marker at both mRNA and protein levels
por: Rondeau, S, et al.
Publicado: (2015)

Evolution of synchronous female bilateral breast cancers and response to treatment
por: Hamy, Anne-Sophie, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_u4rkf9n00q30n1schssas2lppk