Myeloid cell‐derived tumor necrosis factor‐alpha promotes sarcopenia and regulates muscle cell fusion with aging muscle fibers

Sarcopenia is age‐related muscle wasting that lacks effective therapeutic interventions. We found that systemic ablation of tumor necrosis factor‐α (TNF‐α) prevented sarcopenia and prevented age‐related change in muscle fiber phenotype. Furthermore, TNF‐α ablation reduced the number of satellite cel...

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Detalles Bibliográficos
Autores principales: Wang, Ying, Welc, Steven S., Wehling‐Henricks, Michelle, Tidball, James G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260911/
https://www.ncbi.nlm.nih.gov/pubmed/30256507
http://dx.doi.org/10.1111/acel.12828

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260911/
https://www.ncbi.nlm.nih.gov/pubmed/30256507
http://dx.doi.org/10.1111/acel.12828

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