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Clinicopathological analysis of odontogenic tumors over 22 years period: Experience of a single center in northeastern Brazil

BACKGROUND: Odontogenic tumors (OTs) are uncommon neoplastic lesions of the maxilla and mandible, which present difficult diagnosis and therapeutics. This paper aims to determine the frequency and distribution of OTs, over a period of 22 years, at a public university in Northeastern Brazil. MATERIAL...

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Autores principales: de Medeiros, Wenya-Kayse-Duarte, da Silva, Leorik-Pereira, Santos, Pedro-Paulo-de Andrade, Pinto, Leão-Pereira, de Souza, Lélia-Batista
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medicina Oral S.L. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261000/
https://www.ncbi.nlm.nih.gov/pubmed/30341267
http://dx.doi.org/10.4317/medoral.22618
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author de Medeiros, Wenya-Kayse-Duarte
da Silva, Leorik-Pereira
Santos, Pedro-Paulo-de Andrade
Pinto, Leão-Pereira
de Souza, Lélia-Batista
author_facet de Medeiros, Wenya-Kayse-Duarte
da Silva, Leorik-Pereira
Santos, Pedro-Paulo-de Andrade
Pinto, Leão-Pereira
de Souza, Lélia-Batista
author_sort de Medeiros, Wenya-Kayse-Duarte
collection PubMed
description BACKGROUND: Odontogenic tumors (OTs) are uncommon neoplastic lesions of the maxilla and mandible, which present difficult diagnosis and therapeutics. This paper aims to determine the frequency and distribution of OTs, over a period of 22 years, at a public university in Northeastern Brazil. MATERIAL AND METHODS: We reviewed all cases of OTs from oral pathology laboratory of Federal University of Rio Grande do Norte (UFRN), from 1996 to 2017. The tumors were classified according to the latest (2017) World Health Organization Classification of Tumors. Data on age, gender, anatomic site, symptomatology, radiographic findings and tumor size were analyzed. RESULTS: In the analyzed period, 247 cases of OTs were diagnosed. Epithelial tumors were more common with 127 cases (51.8%). The most common tumors were ameloblastoma (n = 112 / 45.4%), odontoma (n = 89 / 36.1%) and odontogenic myxoma (n = 17 / 6.9%). Malignant odontogenic tumors were extremely rare in the studied population with only 2 cases (0.8%) of diagnosed carcinomas. These tumors were diagnosed in a wide age range, from 5 to 81 years, being more common in the second and third decades of life. In general, the mandible was the most affected anatomic site (n = 162/66%) and the mandible:maxilla ratio was of 2:1. Ameloblastoma was the tumor with the highest number of symptomatic cases (n = 26) and with the highest mean size (cm) with 4.5cm. CONCLUSIONS: Odontogenic tumors were rare in the sample studied (2.2%), with ameloblastoma and odontoma being the most common tumors. Continuous studies that show the characteristics of these lesions are fundamental, especially after modifications in the international classification. Key words:Odontogenic tumors, jaw neoplasms, epidemiology, oral pathology.
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spelling pubmed-62610002018-12-03 Clinicopathological analysis of odontogenic tumors over 22 years period: Experience of a single center in northeastern Brazil de Medeiros, Wenya-Kayse-Duarte da Silva, Leorik-Pereira Santos, Pedro-Paulo-de Andrade Pinto, Leão-Pereira de Souza, Lélia-Batista Med Oral Patol Oral Cir Bucal Research BACKGROUND: Odontogenic tumors (OTs) are uncommon neoplastic lesions of the maxilla and mandible, which present difficult diagnosis and therapeutics. This paper aims to determine the frequency and distribution of OTs, over a period of 22 years, at a public university in Northeastern Brazil. MATERIAL AND METHODS: We reviewed all cases of OTs from oral pathology laboratory of Federal University of Rio Grande do Norte (UFRN), from 1996 to 2017. The tumors were classified according to the latest (2017) World Health Organization Classification of Tumors. Data on age, gender, anatomic site, symptomatology, radiographic findings and tumor size were analyzed. RESULTS: In the analyzed period, 247 cases of OTs were diagnosed. Epithelial tumors were more common with 127 cases (51.8%). The most common tumors were ameloblastoma (n = 112 / 45.4%), odontoma (n = 89 / 36.1%) and odontogenic myxoma (n = 17 / 6.9%). Malignant odontogenic tumors were extremely rare in the studied population with only 2 cases (0.8%) of diagnosed carcinomas. These tumors were diagnosed in a wide age range, from 5 to 81 years, being more common in the second and third decades of life. In general, the mandible was the most affected anatomic site (n = 162/66%) and the mandible:maxilla ratio was of 2:1. Ameloblastoma was the tumor with the highest number of symptomatic cases (n = 26) and with the highest mean size (cm) with 4.5cm. CONCLUSIONS: Odontogenic tumors were rare in the sample studied (2.2%), with ameloblastoma and odontoma being the most common tumors. Continuous studies that show the characteristics of these lesions are fundamental, especially after modifications in the international classification. Key words:Odontogenic tumors, jaw neoplasms, epidemiology, oral pathology. Medicina Oral S.L. 2018-11 2018-11-21 /pmc/articles/PMC6261000/ /pubmed/30341267 http://dx.doi.org/10.4317/medoral.22618 Text en Copyright: © 2018 Medicina Oral S.L. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
de Medeiros, Wenya-Kayse-Duarte
da Silva, Leorik-Pereira
Santos, Pedro-Paulo-de Andrade
Pinto, Leão-Pereira
de Souza, Lélia-Batista
Clinicopathological analysis of odontogenic tumors over 22 years period: Experience of a single center in northeastern Brazil
title Clinicopathological analysis of odontogenic tumors over 22 years period: Experience of a single center in northeastern Brazil
title_full Clinicopathological analysis of odontogenic tumors over 22 years period: Experience of a single center in northeastern Brazil
title_fullStr Clinicopathological analysis of odontogenic tumors over 22 years period: Experience of a single center in northeastern Brazil
title_full_unstemmed Clinicopathological analysis of odontogenic tumors over 22 years period: Experience of a single center in northeastern Brazil
title_short Clinicopathological analysis of odontogenic tumors over 22 years period: Experience of a single center in northeastern Brazil
title_sort clinicopathological analysis of odontogenic tumors over 22 years period: experience of a single center in northeastern brazil
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261000/
https://www.ncbi.nlm.nih.gov/pubmed/30341267
http://dx.doi.org/10.4317/medoral.22618
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