Cargando…

Clinical and neonatal outcomes of patients of different ages following transfer of thawed cleavage embryos and blastocysts cultured from thawed cleavage-stage embryos

BACKGROUND: Frozen-thawed embryo transfer (FET) has become a routine procedure in assisted reproductive technology (ART). In FET, although blastocysts cultured from thawed cleavage-stage embryos are associated with better perinatal outcomes. it may increase cycle cancellation due to no suitable embr...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhou, Qin-Wei, Jing, Shuang, Xu, Li, Guo, Hui, Lu, Chang-Fu, Gong, Fei, Lu, Guang-Xiu, Lin, Ge, Gu, Yi-Fan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261106/
https://www.ncbi.nlm.nih.gov/pubmed/30475822
http://dx.doi.org/10.1371/journal.pone.0207340
_version_ 1783374922017406976
author Zhou, Qin-Wei
Jing, Shuang
Xu, Li
Guo, Hui
Lu, Chang-Fu
Gong, Fei
Lu, Guang-Xiu
Lin, Ge
Gu, Yi-Fan
author_facet Zhou, Qin-Wei
Jing, Shuang
Xu, Li
Guo, Hui
Lu, Chang-Fu
Gong, Fei
Lu, Guang-Xiu
Lin, Ge
Gu, Yi-Fan
author_sort Zhou, Qin-Wei
collection PubMed
description BACKGROUND: Frozen-thawed embryo transfer (FET) has become a routine procedure in assisted reproductive technology (ART). In FET, although blastocysts cultured from thawed cleavage-stage embryos are associated with better perinatal outcomes. it may increase cycle cancellation due to no suitable embryo to transfer. The overall clinical outcomes following transfer of thawed cleavage-stage FET and blastocysts cultured from thawed cleavage-stage embryos in young and advanced age patients remains unclear. Therefore, we aimed to identify the optimal FET strategy in young and advanced age women who undergo FET. METHODS: This retrospective study included 16,387 thaw cycles. We retrospectively analyzed data of couples who had completed the first FET cycle. Two FET strategies were studied: transfer of thawed cleavage-stage embryos (strategy A) or blastocysts cultured from thawed cleavage-stage embryos (strategy B). The clinical and neonatal outcomes of two FET strategies were compared in young (<35 years) and advanced (≥35 years) age women. RESULTS: In young women, the clinical outcomes per transfer cycle were better in strategy B than strategy A. While the clinical pregnancy (59.29%, 52.60%) and live birth rates (49.37%, 43.88%) per thaw cycle were significantly higher in strategy A than in B. In women of advanced age, the clinical outcomes per transfer cycle were still better in strategy B than in A, and the clinical pregnancy (36.44%, 39.66%) and live birth rates (25.70%, 30.00%) per thaw cycle were significantly higher in strategy B than in A. CONCLUSIONS: FET of blastocysts cultured from cleavage-stage embryos showed higher efficiency for per transfer cycle whether in younger or advanced age women. Whereas, when cycle cancellations due to no suitable embryo to transfer were considered, cleavage-stage FET was found to be more suitable for younger women, while FET of blastocysts cultured from cleavage-stage embryos was better suited for women of advanced age.
format Online
Article
Text
id pubmed-6261106
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-62611062018-12-06 Clinical and neonatal outcomes of patients of different ages following transfer of thawed cleavage embryos and blastocysts cultured from thawed cleavage-stage embryos Zhou, Qin-Wei Jing, Shuang Xu, Li Guo, Hui Lu, Chang-Fu Gong, Fei Lu, Guang-Xiu Lin, Ge Gu, Yi-Fan PLoS One Research Article BACKGROUND: Frozen-thawed embryo transfer (FET) has become a routine procedure in assisted reproductive technology (ART). In FET, although blastocysts cultured from thawed cleavage-stage embryos are associated with better perinatal outcomes. it may increase cycle cancellation due to no suitable embryo to transfer. The overall clinical outcomes following transfer of thawed cleavage-stage FET and blastocysts cultured from thawed cleavage-stage embryos in young and advanced age patients remains unclear. Therefore, we aimed to identify the optimal FET strategy in young and advanced age women who undergo FET. METHODS: This retrospective study included 16,387 thaw cycles. We retrospectively analyzed data of couples who had completed the first FET cycle. Two FET strategies were studied: transfer of thawed cleavage-stage embryos (strategy A) or blastocysts cultured from thawed cleavage-stage embryos (strategy B). The clinical and neonatal outcomes of two FET strategies were compared in young (<35 years) and advanced (≥35 years) age women. RESULTS: In young women, the clinical outcomes per transfer cycle were better in strategy B than strategy A. While the clinical pregnancy (59.29%, 52.60%) and live birth rates (49.37%, 43.88%) per thaw cycle were significantly higher in strategy A than in B. In women of advanced age, the clinical outcomes per transfer cycle were still better in strategy B than in A, and the clinical pregnancy (36.44%, 39.66%) and live birth rates (25.70%, 30.00%) per thaw cycle were significantly higher in strategy B than in A. CONCLUSIONS: FET of blastocysts cultured from cleavage-stage embryos showed higher efficiency for per transfer cycle whether in younger or advanced age women. Whereas, when cycle cancellations due to no suitable embryo to transfer were considered, cleavage-stage FET was found to be more suitable for younger women, while FET of blastocysts cultured from cleavage-stage embryos was better suited for women of advanced age. Public Library of Science 2018-11-26 /pmc/articles/PMC6261106/ /pubmed/30475822 http://dx.doi.org/10.1371/journal.pone.0207340 Text en © 2018 Zhou et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Zhou, Qin-Wei
Jing, Shuang
Xu, Li
Guo, Hui
Lu, Chang-Fu
Gong, Fei
Lu, Guang-Xiu
Lin, Ge
Gu, Yi-Fan
Clinical and neonatal outcomes of patients of different ages following transfer of thawed cleavage embryos and blastocysts cultured from thawed cleavage-stage embryos
title Clinical and neonatal outcomes of patients of different ages following transfer of thawed cleavage embryos and blastocysts cultured from thawed cleavage-stage embryos
title_full Clinical and neonatal outcomes of patients of different ages following transfer of thawed cleavage embryos and blastocysts cultured from thawed cleavage-stage embryos
title_fullStr Clinical and neonatal outcomes of patients of different ages following transfer of thawed cleavage embryos and blastocysts cultured from thawed cleavage-stage embryos
title_full_unstemmed Clinical and neonatal outcomes of patients of different ages following transfer of thawed cleavage embryos and blastocysts cultured from thawed cleavage-stage embryos
title_short Clinical and neonatal outcomes of patients of different ages following transfer of thawed cleavage embryos and blastocysts cultured from thawed cleavage-stage embryos
title_sort clinical and neonatal outcomes of patients of different ages following transfer of thawed cleavage embryos and blastocysts cultured from thawed cleavage-stage embryos
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261106/
https://www.ncbi.nlm.nih.gov/pubmed/30475822
http://dx.doi.org/10.1371/journal.pone.0207340
work_keys_str_mv AT zhouqinwei clinicalandneonataloutcomesofpatientsofdifferentagesfollowingtransferofthawedcleavageembryosandblastocystsculturedfromthawedcleavagestageembryos
AT jingshuang clinicalandneonataloutcomesofpatientsofdifferentagesfollowingtransferofthawedcleavageembryosandblastocystsculturedfromthawedcleavagestageembryos
AT xuli clinicalandneonataloutcomesofpatientsofdifferentagesfollowingtransferofthawedcleavageembryosandblastocystsculturedfromthawedcleavagestageembryos
AT guohui clinicalandneonataloutcomesofpatientsofdifferentagesfollowingtransferofthawedcleavageembryosandblastocystsculturedfromthawedcleavagestageembryos
AT luchangfu clinicalandneonataloutcomesofpatientsofdifferentagesfollowingtransferofthawedcleavageembryosandblastocystsculturedfromthawedcleavagestageembryos
AT gongfei clinicalandneonataloutcomesofpatientsofdifferentagesfollowingtransferofthawedcleavageembryosandblastocystsculturedfromthawedcleavagestageembryos
AT luguangxiu clinicalandneonataloutcomesofpatientsofdifferentagesfollowingtransferofthawedcleavageembryosandblastocystsculturedfromthawedcleavagestageembryos
AT linge clinicalandneonataloutcomesofpatientsofdifferentagesfollowingtransferofthawedcleavageembryosandblastocystsculturedfromthawedcleavagestageembryos
AT guyifan clinicalandneonataloutcomesofpatientsofdifferentagesfollowingtransferofthawedcleavageembryosandblastocystsculturedfromthawedcleavagestageembryos