A Case of Nail Psoriasis Successfully Treated with Intralesional Methotrexate

Psoriasis is a chronic inflammatory disease affecting the skin, nails, and joints. About 61% of psoriatic patients have nail involvement that can cause a significant social problem. Treating nail psoriasis is challenging but can improve the health outcomes and quality of life of patients. Treatment...

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Autores principales: Mokni, Sana, Ameur, Khaoula, Ghariani, Najet, Sriha, Badreddine, Belajouza, Colandane, Denguezli, Mohamed, Nouira, Rafiaa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261120/
https://www.ncbi.nlm.nih.gov/pubmed/30255281
http://dx.doi.org/10.1007/s13555-018-0261-2
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author Mokni, Sana
Ameur, Khaoula
Ghariani, Najet
Sriha, Badreddine
Belajouza, Colandane
Denguezli, Mohamed
Nouira, Rafiaa
author_facet Mokni, Sana
Ameur, Khaoula
Ghariani, Najet
Sriha, Badreddine
Belajouza, Colandane
Denguezli, Mohamed
Nouira, Rafiaa
author_sort Mokni, Sana
collection PubMed
description Psoriasis is a chronic inflammatory disease affecting the skin, nails, and joints. About 61% of psoriatic patients have nail involvement that can cause a significant social problem. Treating nail psoriasis is challenging but can improve the health outcomes and quality of life of patients. Treatment options available for nail psoriasis including topical therapy, intralesional injections, and systemic and biologic agents have various side effects and some benefits. Management is currently inconclusive. Intralesional injection of methotrexate in nail psoriasis was previously documented in few cases. We present a case of nail psoriasis successfully treated with low-dose intralesional methotrexate with no significant side effects in a 48-year-old psoriatic patient. Given the various side effects of conventional topical and systemic therapies limiting their use, we conclude that intralesional methotrexate injection seems to be a safe and effective treatment option for nail psoriasis. However, large controlled studies are needed.
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spelling pubmed-62611202018-12-11 A Case of Nail Psoriasis Successfully Treated with Intralesional Methotrexate Mokni, Sana Ameur, Khaoula Ghariani, Najet Sriha, Badreddine Belajouza, Colandane Denguezli, Mohamed Nouira, Rafiaa Dermatol Ther (Heidelb) Case Report Psoriasis is a chronic inflammatory disease affecting the skin, nails, and joints. About 61% of psoriatic patients have nail involvement that can cause a significant social problem. Treating nail psoriasis is challenging but can improve the health outcomes and quality of life of patients. Treatment options available for nail psoriasis including topical therapy, intralesional injections, and systemic and biologic agents have various side effects and some benefits. Management is currently inconclusive. Intralesional injection of methotrexate in nail psoriasis was previously documented in few cases. We present a case of nail psoriasis successfully treated with low-dose intralesional methotrexate with no significant side effects in a 48-year-old psoriatic patient. Given the various side effects of conventional topical and systemic therapies limiting their use, we conclude that intralesional methotrexate injection seems to be a safe and effective treatment option for nail psoriasis. However, large controlled studies are needed. Springer Healthcare 2018-09-25 /pmc/articles/PMC6261120/ /pubmed/30255281 http://dx.doi.org/10.1007/s13555-018-0261-2 Text en © The Author(s) 2018 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Case Report
Mokni, Sana
Ameur, Khaoula
Ghariani, Najet
Sriha, Badreddine
Belajouza, Colandane
Denguezli, Mohamed
Nouira, Rafiaa
A Case of Nail Psoriasis Successfully Treated with Intralesional Methotrexate
title A Case of Nail Psoriasis Successfully Treated with Intralesional Methotrexate
title_full A Case of Nail Psoriasis Successfully Treated with Intralesional Methotrexate
title_fullStr A Case of Nail Psoriasis Successfully Treated with Intralesional Methotrexate
title_full_unstemmed A Case of Nail Psoriasis Successfully Treated with Intralesional Methotrexate
title_short A Case of Nail Psoriasis Successfully Treated with Intralesional Methotrexate
title_sort case of nail psoriasis successfully treated with intralesional methotrexate
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261120/
https://www.ncbi.nlm.nih.gov/pubmed/30255281
http://dx.doi.org/10.1007/s13555-018-0261-2
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