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Nonfat milk attenuates acute hyperglycemia in individuals with android obesity: A randomized control trial

BACKGROUND: Elevated android body fat increases the risk of developing cardiometabolic diseases. Postprandial hyperglycemia contributes to the proatherogenic metabolic state evident in android adiposity. Due to the insulinotropic effect of milk‐derived proteins, postprandial hyperglycemia has been s...

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Autores principales: Leary, Miriam P., Roy, Stephen J., Lim, Jisok, Park, Wonil, Ferrari, Rodrigo, Eaves, Jared, Machin, Daniel R., Tanaka, Hirofumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261169/
https://www.ncbi.nlm.nih.gov/pubmed/30510711
http://dx.doi.org/10.1002/fsn3.767
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author Leary, Miriam P.
Roy, Stephen J.
Lim, Jisok
Park, Wonil
Ferrari, Rodrigo
Eaves, Jared
Machin, Daniel R.
Tanaka, Hirofumi
author_facet Leary, Miriam P.
Roy, Stephen J.
Lim, Jisok
Park, Wonil
Ferrari, Rodrigo
Eaves, Jared
Machin, Daniel R.
Tanaka, Hirofumi
author_sort Leary, Miriam P.
collection PubMed
description BACKGROUND: Elevated android body fat increases the risk of developing cardiometabolic diseases. Postprandial hyperglycemia contributes to the proatherogenic metabolic state evident in android adiposity. Due to the insulinotropic effect of milk‐derived proteins, postprandial hyperglycemia has been shown to be reduced with the addition of dairy products. The purpose of this study was to determine whether one serving of nonfat milk added to an oral glucose tolerance test (OGTT) could attenuate postprandial hyperglycemia in individuals with elevated android adiposity and whether these improvements would be associated with metabolic and/or peripheral hemodynamic effects. METHODS: In this placebo‐controlled, randomized, crossover experimental study, 29 overweight/obese adults (26 ± 1 year) consumed an OGTT beverage (75 g glucose) combined with either nonfat milk (227 g) or a placebo control (12 g lactose + 8 g protein + 207 g water) that was matched for both carbohydrate and protein quantities. RESULTS: In the whole sample, blood glucose and insulin concentrations increased over time in both trials with no significant differences between trials. Relative increases in peak blood glucose response were significantly related to android body fat (p < 0.05). The subjects in the highest tertiles of android body fat displayed attenuated hyperglycemic responses as well as improvements in flow‐mediated dilation (FMD) after milk intake. CONCLUSIONS: A single serving of nonfat milk may attenuate acute hyperglycemia in individuals with elevated android body fat offering a simple and convenient option for managing elevations in blood glucose.
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spelling pubmed-62611692018-12-03 Nonfat milk attenuates acute hyperglycemia in individuals with android obesity: A randomized control trial Leary, Miriam P. Roy, Stephen J. Lim, Jisok Park, Wonil Ferrari, Rodrigo Eaves, Jared Machin, Daniel R. Tanaka, Hirofumi Food Sci Nutr Original Research BACKGROUND: Elevated android body fat increases the risk of developing cardiometabolic diseases. Postprandial hyperglycemia contributes to the proatherogenic metabolic state evident in android adiposity. Due to the insulinotropic effect of milk‐derived proteins, postprandial hyperglycemia has been shown to be reduced with the addition of dairy products. The purpose of this study was to determine whether one serving of nonfat milk added to an oral glucose tolerance test (OGTT) could attenuate postprandial hyperglycemia in individuals with elevated android adiposity and whether these improvements would be associated with metabolic and/or peripheral hemodynamic effects. METHODS: In this placebo‐controlled, randomized, crossover experimental study, 29 overweight/obese adults (26 ± 1 year) consumed an OGTT beverage (75 g glucose) combined with either nonfat milk (227 g) or a placebo control (12 g lactose + 8 g protein + 207 g water) that was matched for both carbohydrate and protein quantities. RESULTS: In the whole sample, blood glucose and insulin concentrations increased over time in both trials with no significant differences between trials. Relative increases in peak blood glucose response were significantly related to android body fat (p < 0.05). The subjects in the highest tertiles of android body fat displayed attenuated hyperglycemic responses as well as improvements in flow‐mediated dilation (FMD) after milk intake. CONCLUSIONS: A single serving of nonfat milk may attenuate acute hyperglycemia in individuals with elevated android body fat offering a simple and convenient option for managing elevations in blood glucose. John Wiley and Sons Inc. 2018-09-12 /pmc/articles/PMC6261169/ /pubmed/30510711 http://dx.doi.org/10.1002/fsn3.767 Text en © 2018 The Authors. Food Science & Nutrition published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Leary, Miriam P.
Roy, Stephen J.
Lim, Jisok
Park, Wonil
Ferrari, Rodrigo
Eaves, Jared
Machin, Daniel R.
Tanaka, Hirofumi
Nonfat milk attenuates acute hyperglycemia in individuals with android obesity: A randomized control trial
title Nonfat milk attenuates acute hyperglycemia in individuals with android obesity: A randomized control trial
title_full Nonfat milk attenuates acute hyperglycemia in individuals with android obesity: A randomized control trial
title_fullStr Nonfat milk attenuates acute hyperglycemia in individuals with android obesity: A randomized control trial
title_full_unstemmed Nonfat milk attenuates acute hyperglycemia in individuals with android obesity: A randomized control trial
title_short Nonfat milk attenuates acute hyperglycemia in individuals with android obesity: A randomized control trial
title_sort nonfat milk attenuates acute hyperglycemia in individuals with android obesity: a randomized control trial
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261169/
https://www.ncbi.nlm.nih.gov/pubmed/30510711
http://dx.doi.org/10.1002/fsn3.767
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