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Genetically-engineered human cortical spheroid models of Tuberous Sclerosis

Tuberous Sclerosis Complex (TSC) is a multi-system developmental disorder caused by mutations in the TSC1 or TSC2 genes, whose protein products are negative regulators of mTOR complex 1 signaling. Hallmark pathologies of TSC are cortical tubers; regions of dysmorphic, disorganized neurons and glia i...

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Detalles Bibliográficos
Autores principales:	Blair, John D., Hockemeyer, Dirk, Bateup, Helen S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261470/ https://www.ncbi.nlm.nih.gov/pubmed/30127391 http://dx.doi.org/10.1038/s41591-018-0139-y

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