Deficiency of the pattern-recognition receptor CD14 protects against joint pathology and functional decline in a murine model of osteoarthritis

OBJECTIVE: CD14 is a monocyte/macrophage pattern-recognition receptor that modulates innate inflammatory signaling. Soluble CD14 levels in knee OA synovial fluids are associated with symptoms and progression of disease. Here we investigate the role of this receptor in development of OA using a murin...

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Detalles Bibliográficos
Autores principales: Sambamurthy, Nisha, Zhou, Cheng, Nguyen, Vu, Smalley, Ryan, Hankenson, Kurt D., Dodge, George R., Scanzello, Carla R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261538/
https://www.ncbi.nlm.nih.gov/pubmed/30485272
http://dx.doi.org/10.1371/journal.pone.0206217

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261538/
https://www.ncbi.nlm.nih.gov/pubmed/30485272
http://dx.doi.org/10.1371/journal.pone.0206217

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