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Functional architecture of the foveola revealed in the living primate
The primate foveola, with its high cone density and magnified cortical representation, is exquisitely specialized for high-resolution spatial vision. However, uncovering the wiring of retinal circuitry responsible for this performance has been challenging due to the difficulty in recording receptive...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261564/ https://www.ncbi.nlm.nih.gov/pubmed/30485298 http://dx.doi.org/10.1371/journal.pone.0207102 |
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author | McGregor, Juliette E. Yin, Lu Yang, Qiang Godat, Tyler Huynh, Khang T. Zhang, Jie Williams, David R. Merigan, William H. |
author_facet | McGregor, Juliette E. Yin, Lu Yang, Qiang Godat, Tyler Huynh, Khang T. Zhang, Jie Williams, David R. Merigan, William H. |
author_sort | McGregor, Juliette E. |
collection | PubMed |
description | The primate foveola, with its high cone density and magnified cortical representation, is exquisitely specialized for high-resolution spatial vision. However, uncovering the wiring of retinal circuitry responsible for this performance has been challenging due to the difficulty in recording receptive fields of foveal retinal ganglion cells (RGCs) in vivo. In this study, we use adaptive optics scanning laser ophthalmoscopy (AOSLO) to image the calcium responses of RGCs in the living primate, with a stable, high precision visual stimulus that allowed us to localize the receptive fields of hundreds of foveal ganglion cells. This approach revealed a precisely radial organization of foveal RGCs, despite the many distortions possible during the extended developmental migration of foveal cells. By back projecting the line connecting RGC somas to their receptive fields, we have been able to define the ‘physiological center’ of the foveola, locating the vertical meridian separating left and right hemifields in vivo. |
format | Online Article Text |
id | pubmed-6261564 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-62615642018-12-19 Functional architecture of the foveola revealed in the living primate McGregor, Juliette E. Yin, Lu Yang, Qiang Godat, Tyler Huynh, Khang T. Zhang, Jie Williams, David R. Merigan, William H. PLoS One Research Article The primate foveola, with its high cone density and magnified cortical representation, is exquisitely specialized for high-resolution spatial vision. However, uncovering the wiring of retinal circuitry responsible for this performance has been challenging due to the difficulty in recording receptive fields of foveal retinal ganglion cells (RGCs) in vivo. In this study, we use adaptive optics scanning laser ophthalmoscopy (AOSLO) to image the calcium responses of RGCs in the living primate, with a stable, high precision visual stimulus that allowed us to localize the receptive fields of hundreds of foveal ganglion cells. This approach revealed a precisely radial organization of foveal RGCs, despite the many distortions possible during the extended developmental migration of foveal cells. By back projecting the line connecting RGC somas to their receptive fields, we have been able to define the ‘physiological center’ of the foveola, locating the vertical meridian separating left and right hemifields in vivo. Public Library of Science 2018-11-28 /pmc/articles/PMC6261564/ /pubmed/30485298 http://dx.doi.org/10.1371/journal.pone.0207102 Text en © 2018 McGregor et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article McGregor, Juliette E. Yin, Lu Yang, Qiang Godat, Tyler Huynh, Khang T. Zhang, Jie Williams, David R. Merigan, William H. Functional architecture of the foveola revealed in the living primate |
title | Functional architecture of the foveola revealed in the living primate |
title_full | Functional architecture of the foveola revealed in the living primate |
title_fullStr | Functional architecture of the foveola revealed in the living primate |
title_full_unstemmed | Functional architecture of the foveola revealed in the living primate |
title_short | Functional architecture of the foveola revealed in the living primate |
title_sort | functional architecture of the foveola revealed in the living primate |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261564/ https://www.ncbi.nlm.nih.gov/pubmed/30485298 http://dx.doi.org/10.1371/journal.pone.0207102 |
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