Novel high–throughput myofibroblast assays identify agonists with therapeutic potential in pulmonary fibrosis that act via EP(2) and EP(4) receptors

Pathological features of pulmonary fibrosis include accumulation of myofibroblasts and increased extracellular matrix (ECM) deposition in lung tissue. Contractile α–smooth muscle actin (α–SMA)–expressing myofibroblasts that produce and secrete ECM are key effector cells of the disease and therefore...

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Detalles Bibliográficos
Autores principales: Sieber, Patrick, Schäfer, Anny, Lieberherr, Raphael, Le Goff, François, Stritt, Manuel, Welford, Richard W. D., Gatfield, John, Peter, Oliver, Nayler, Oliver, Lüthi, Urs
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261607/
https://www.ncbi.nlm.nih.gov/pubmed/30485339
http://dx.doi.org/10.1371/journal.pone.0207872

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