Single-cell RNA sequencing unveils an IL-10-producing helper subset that sustains humoral immunity during persistent infection

During chronic viral infection, the inflammatory function of CD4 T-cells becomes gradually attenuated. Concurrently, Th1 cells progressively acquire the capacity to secrete the cytokine IL-10, a potent suppressor of antiviral T cell responses. To determine the transcriptional changes that underlie t...

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Detalles Bibliográficos
Autores principales: Xin, Gang, Zander, Ryan, Schauder, David M., Chen, Yao, Weinstein, Jason S., Drobyski, William R., Tarakanova, Vera, Craft, Joseph, Cui, Weiguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261948/
https://www.ncbi.nlm.nih.gov/pubmed/30487586
http://dx.doi.org/10.1038/s41467-018-07492-4

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