Cargando…

Hif1a inactivation rescues photoreceptor degeneration induced by a chronic hypoxia-like stress

Reduced choroidal blood flow and tissue changes in the ageing human eye impair oxygen delivery to photoreceptors and the retinal pigment epithelium. As a consequence, mild but chronic hypoxia may develop and disturb cell metabolism, function and ultimately survival, potentially contributing to retin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Barben, Maya, Ail, Divya, Storti, Federica, Klee, Katrin, Schori, Christian, Samardzija, Marijana, Michalakis, Stylianos, Biel, Martin, Meneau, Isabelle, Blaser, Frank, Barthelmes, Daniel, Grimm, Christian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6261999/ https://www.ncbi.nlm.nih.gov/pubmed/29666476 http://dx.doi.org/10.1038/s41418-018-0094-7

Ejemplares similares

Hif1a and Hif2a can be safely inactivated in cone photoreceptors
por: Samardzija, Marijana, et al.
Publicado: (2019)

Targeting Hif1a rescues cone degeneration and prevents subretinal neovascularization in a model of chronic hypoxia
por: Barben, Maya, et al.
Publicado: (2018)

Digoxin-induced retinal degeneration depends on rhodopsin
por: Landfried, Britta, et al.
Publicado: (2017)

Stanniocalcin2, but Not Stanniocalcin1, Responds to Hypoxia in a HIF1-Dependent Manner in the Retina
por: Ail, Divya, et al.
Publicado: (2022)

Elovl4 5-bp deletion does not accelerate cone photoreceptor degeneration in an all-cone mouse
por: Schori, Christian, et al.
Publicado: (2018)

Endogenous leukemia inhibitory factor protects photoreceptor cells against light-induced degeneration
por: Bürgi, Sandra, et al.
Publicado: (2009)

Circadian regulation of vertebrate cone photoreceptor function
por: Zang, Jingjing, et al.
Publicado: (2021)

Impaired ABCA1/ABCG1-mediated lipid efflux in the mouse retinal pigment epithelium (RPE) leads to retinal degeneration
por: Storti, Federica, et al.
Publicado: (2019)

The Expression of Decidual Protein Induced by Progesterone (DEPP) Is Controlled by Three Distal Consensus Hypoxia Responsive Element (HRE) in Hypoxic Retinal Epithelial Cells
por: Klee, Katrin, et al.
Publicado: (2020)

CDC42 Is Required for Tissue Lamination and Cell Survival in the Mouse Retina
por: Heynen, Severin Reinhard, et al.
Publicado: (2013)

Deficits in mitochondrial TCA cycle and OXPHOS precede rod photoreceptor degeneration during chronic HIF activation
por: Todorova, Vyara, et al.
Publicado: (2023)

Plasma levels of hypoxia-regulated factors in patients with age-related macular degeneration
por: Ioanna, Zygoula, et al.
Publicado: (2017)

Expression of leukemia inhibitory factor in Müller glia cells is regulated by a redox-dependent mRNA stability mechanism
por: Agca, Cavit, et al.
Publicado: (2015)

AAV Vectors for FRET-Based Analysis of Protein-Protein Interactions in Photoreceptor Outer Segments
por: Becirovic, Elvir, et al.
Publicado: (2016)

Gene Therapy Regenerates Protein Expression in Cone Photoreceptors in Rpe65(R91W/R91W) Mice
por: Kostic, Corinne, et al.
Publicado: (2011)

Ca(v)1.4 L-Type Calcium Channels Contribute to Calpain Activation in Degenerating Photoreceptors of rd1 Mice
por: Schön, Christian, et al.
Publicado: (2016)

Retinal Layer Separation (ReLayS) method enables the molecular analysis of photoreceptor segments and cell bodies, as well as the inner retina
por: Todorova, Vyara, et al.
Publicado: (2022)

Early Microglia Activation Precedes Photoreceptor Degeneration in a Mouse Model of CNGB1-Linked Retinitis Pigmentosa
por: Blank, Thomas, et al.
Publicado: (2018)

Blue light-induced retinal lesions, intraretinal vascular leakage and edema formation in the all-cone mouse retina
por: Geiger, P, et al.
Publicado: (2015)

The erythropoietin receptor is not required for the development, function, and aging of rods and cells in the retinal periphery
por: Caprara, Christian, et al.
Publicado: (2014)

Novel AAV capsids for intravitreal gene therapy of photoreceptor disorders
por: Pavlou, Marina, et al.
Publicado: (2021)

Retinal Cyclic Nucleotide-Gated Channels: From Pathophysiology to Therapy
por: Michalakis, Stylianos, et al.
Publicado: (2018)

Retinal degeneration modulates intracellular localization of CDC42 in photoreceptors
por: Heynen, S.R., et al.
Publicado: (2011)

Quick and reliable method for retina dissociation and separation of rod photoreceptor perikarya from adult mice
por: Feodorova, Yana, et al.
Publicado: (2015)

DNA methylation and differential gene regulation in photoreceptor cell death
por: Farinelli, P, et al.
Publicado: (2014)

p38 MAPK signaling acts upstream of LIF-dependent neuroprotection during photoreceptor degeneration
por: Agca, C, et al.
Publicado: (2013)

The cGMP-Dependent Protein Kinase 2 Contributes to Cone Photoreceptor Degeneration in the Cnga3-Deficient Mouse Model of Achromatopsia
por: Koch, Mirja, et al.
Publicado: (2020)

Single-cell RNA sequencing of the retina in a model of retinitis pigmentosa reveals early responses to degeneration in rods and cones
por: Karademir, Duygu, et al.
Publicado: (2022)

More than meets the eye: The role of microglia in healthy and diseased retina
por: Murenu, Elisa, et al.
Publicado: (2022)

In Vivo Analysis of Disease-Associated Point Mutations Unveils Profound Differences in mRNA Splicing of Peripherin-2 in Rod and Cone Photoreceptors
por: Becirovic, Elvir, et al.
Publicado: (2016)

TPC2 promotes choroidal angiogenesis and inflammation in a mouse model of neovascular age-related macular degeneration
por: Li, Yanfen, et al.
Publicado: (2021)

Metabolic rescue of cone photoreceptors in retinitis pigmentosa
por: Kaplan, Henry J., et al.
Publicado: (2021)

Physiological roles of cGMP-gated channels: lessons from mouse models and human channelopathies
por: Biel, Martin, et al.
Publicado: (2009)

The cGMP-Dependent Protein Kinase II Is an Inhibitory Modulator of the Hyperpolarization-Activated HCN2 Channel
por: Hammelmann, Verena, et al.
Publicado: (2011)

A30P α-Synuclein interferes with the stable integration of adult-born neurons into the olfactory network
por: Neuner, Johanna, et al.
Publicado: (2014)

Biology, Pathobiology and Gene Therapy of CNG Channel-Related Retinopathies
por: Gerhardt, Maximilian J., et al.
Publicado: (2023)

Morpho‐Rheological Fingerprinting of Rod Photoreceptors Using Real‐Time Deformability Cytometry
por: Santos‐Ferreira, Tiago, et al.
Publicado: (2019)

Analysis of the retinal gene expression profile after hypoxic preconditioning identifies candidate genes for neuroprotection
por: Thiersch, Markus, et al.
Publicado: (2008)

The Retinitis Pigmentosa Mutation c.3444+1G>A in CNGB1 Results in Skipping of Exon 32
por: Becirovic, Elvir, et al.
Publicado: (2010)

Optogenetic Control of Neural Circuits in the Mongolian Gerbil
por: Keplinger, Stefan, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_3rnj8mj2bqn5nlg3fe1hq74e1t