IMB-T130 targets 3-dehydroquinate synthase and inhibits Mycobacterium tuberculosis

The anti-tuberculosis (TB) agent IMB-T130 was speculated to be a multi-target compound. In this research, we found that IMB-T130 inhibits the catalytic activity of Mycobacterium tuberculosis 3-dehydroquinate synthase (MtDHQS), the enzyme in the second step of the shikimate pathway. IMB-T130 was iden...

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Detalles Bibliográficos
Autores principales: Zhu, Ningyu, Wang, Xia, Li, Dongsheng, Lin, Yuan, You, Xuefu, Jiang, Jiandong, Xu, Yanni, Jiang, Wei, Si, Shuyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262012/
https://www.ncbi.nlm.nih.gov/pubmed/30487577
http://dx.doi.org/10.1038/s41598-018-35701-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262012/
https://www.ncbi.nlm.nih.gov/pubmed/30487577
http://dx.doi.org/10.1038/s41598-018-35701-z

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