Cargando…
Prognostic Analysis of Limited Resection Versus Lobectomy in Stage IA Small Cell Lung Cancer Patients Based on the Surveillance, Epidemiology, and End Results Registry Database
Objective: The prognostic analysis of limited resection vs. lobectomy in stage IA small cell lung cancer (SCLC) remains scarce. Methods: Using the Surveillance, Epidemiology, and End Results registry (SEER) database, we identified patients who were diagnosed with pathological stage IA (T1a/bN0M0) SC...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262036/ https://www.ncbi.nlm.nih.gov/pubmed/30524472 http://dx.doi.org/10.3389/fgene.2018.00568 |
_version_ | 1783375031169974272 |
---|---|
author | Gu, Chang Huang, Zhenyu Dai, Chenyang Wang, Yiting Ren, Yijiu She, Yunlang Su, Hang Chen, Chang |
author_facet | Gu, Chang Huang, Zhenyu Dai, Chenyang Wang, Yiting Ren, Yijiu She, Yunlang Su, Hang Chen, Chang |
author_sort | Gu, Chang |
collection | PubMed |
description | Objective: The prognostic analysis of limited resection vs. lobectomy in stage IA small cell lung cancer (SCLC) remains scarce. Methods: Using the Surveillance, Epidemiology, and End Results registry (SEER) database, we identified patients who were diagnosed with pathological stage IA (T1a/bN0M0) SCLC from 2004 to 2013. The overall survival (OS) and lung cancer-specific survival (LCSS) rates of patients with different treatment schemes were compared in stratification analyses. Univariable and multivariable analyses were also performed to identify the significant predictors of OS and LCSS. Results: In total, we extracted 491 pathological stage IA SCLC patients, 106 (21.6%) of whom received lobectomy, 70 (14.3%) received sublobar resection and 315 (64.1%) received non-surgical treatment, respectively. There were significant differences among the groups based on different treatment schemes in OS (log-rank p < 0.0001) and LCSS (log-rank p < 0.0001). Furthermore, in subgroup analyses, we did not identify any differences between sublober resection group and lobectomy group in OS (log-rank p = 0.14) or LCSS (log-rank p = 0.4565). Patients with four or more lymph node dissection had better prognosis. Multivariable analyses revealed age, laterality, tumor location, and N number were still significant predictors of OS, whereas age, tumor location, and N number were significant predictors of LCSS. Conclusion: Surgery is an important component of multidisciplinary treatment for stage IA SCLC patients and sublober resection is not inferior to lobectomy for the specific patients. |
format | Online Article Text |
id | pubmed-6262036 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-62620362018-12-06 Prognostic Analysis of Limited Resection Versus Lobectomy in Stage IA Small Cell Lung Cancer Patients Based on the Surveillance, Epidemiology, and End Results Registry Database Gu, Chang Huang, Zhenyu Dai, Chenyang Wang, Yiting Ren, Yijiu She, Yunlang Su, Hang Chen, Chang Front Genet Genetics Objective: The prognostic analysis of limited resection vs. lobectomy in stage IA small cell lung cancer (SCLC) remains scarce. Methods: Using the Surveillance, Epidemiology, and End Results registry (SEER) database, we identified patients who were diagnosed with pathological stage IA (T1a/bN0M0) SCLC from 2004 to 2013. The overall survival (OS) and lung cancer-specific survival (LCSS) rates of patients with different treatment schemes were compared in stratification analyses. Univariable and multivariable analyses were also performed to identify the significant predictors of OS and LCSS. Results: In total, we extracted 491 pathological stage IA SCLC patients, 106 (21.6%) of whom received lobectomy, 70 (14.3%) received sublobar resection and 315 (64.1%) received non-surgical treatment, respectively. There were significant differences among the groups based on different treatment schemes in OS (log-rank p < 0.0001) and LCSS (log-rank p < 0.0001). Furthermore, in subgroup analyses, we did not identify any differences between sublober resection group and lobectomy group in OS (log-rank p = 0.14) or LCSS (log-rank p = 0.4565). Patients with four or more lymph node dissection had better prognosis. Multivariable analyses revealed age, laterality, tumor location, and N number were still significant predictors of OS, whereas age, tumor location, and N number were significant predictors of LCSS. Conclusion: Surgery is an important component of multidisciplinary treatment for stage IA SCLC patients and sublober resection is not inferior to lobectomy for the specific patients. Frontiers Media S.A. 2018-11-22 /pmc/articles/PMC6262036/ /pubmed/30524472 http://dx.doi.org/10.3389/fgene.2018.00568 Text en Copyright © 2018 Gu, Huang, Dai, Wang, Ren, She, Su and Chen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Genetics Gu, Chang Huang, Zhenyu Dai, Chenyang Wang, Yiting Ren, Yijiu She, Yunlang Su, Hang Chen, Chang Prognostic Analysis of Limited Resection Versus Lobectomy in Stage IA Small Cell Lung Cancer Patients Based on the Surveillance, Epidemiology, and End Results Registry Database |
title | Prognostic Analysis of Limited Resection Versus Lobectomy in Stage IA Small Cell Lung Cancer Patients Based on the Surveillance, Epidemiology, and End Results Registry Database |
title_full | Prognostic Analysis of Limited Resection Versus Lobectomy in Stage IA Small Cell Lung Cancer Patients Based on the Surveillance, Epidemiology, and End Results Registry Database |
title_fullStr | Prognostic Analysis of Limited Resection Versus Lobectomy in Stage IA Small Cell Lung Cancer Patients Based on the Surveillance, Epidemiology, and End Results Registry Database |
title_full_unstemmed | Prognostic Analysis of Limited Resection Versus Lobectomy in Stage IA Small Cell Lung Cancer Patients Based on the Surveillance, Epidemiology, and End Results Registry Database |
title_short | Prognostic Analysis of Limited Resection Versus Lobectomy in Stage IA Small Cell Lung Cancer Patients Based on the Surveillance, Epidemiology, and End Results Registry Database |
title_sort | prognostic analysis of limited resection versus lobectomy in stage ia small cell lung cancer patients based on the surveillance, epidemiology, and end results registry database |
topic | Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262036/ https://www.ncbi.nlm.nih.gov/pubmed/30524472 http://dx.doi.org/10.3389/fgene.2018.00568 |
work_keys_str_mv | AT guchang prognosticanalysisoflimitedresectionversuslobectomyinstageiasmallcelllungcancerpatientsbasedonthesurveillanceepidemiologyandendresultsregistrydatabase AT huangzhenyu prognosticanalysisoflimitedresectionversuslobectomyinstageiasmallcelllungcancerpatientsbasedonthesurveillanceepidemiologyandendresultsregistrydatabase AT daichenyang prognosticanalysisoflimitedresectionversuslobectomyinstageiasmallcelllungcancerpatientsbasedonthesurveillanceepidemiologyandendresultsregistrydatabase AT wangyiting prognosticanalysisoflimitedresectionversuslobectomyinstageiasmallcelllungcancerpatientsbasedonthesurveillanceepidemiologyandendresultsregistrydatabase AT renyijiu prognosticanalysisoflimitedresectionversuslobectomyinstageiasmallcelllungcancerpatientsbasedonthesurveillanceepidemiologyandendresultsregistrydatabase AT sheyunlang prognosticanalysisoflimitedresectionversuslobectomyinstageiasmallcelllungcancerpatientsbasedonthesurveillanceepidemiologyandendresultsregistrydatabase AT suhang prognosticanalysisoflimitedresectionversuslobectomyinstageiasmallcelllungcancerpatientsbasedonthesurveillanceepidemiologyandendresultsregistrydatabase AT chenchang prognosticanalysisoflimitedresectionversuslobectomyinstageiasmallcelllungcancerpatientsbasedonthesurveillanceepidemiologyandendresultsregistrydatabase |