The Role of Calcium-Permeable AMPARs in Long-Term Potentiation at Principal Neurons in the Rodent Hippocampus

Long-term potentiation (LTP) at hippocampal CA1 synapses is classically triggered by the synaptic activation of NMDA receptors (NMDARs). More recently, it has been shown that calcium-permeable (CP) AMPA receptors (AMPARs) can also trigger synaptic plasticity at these synapses. Here, we review this l...

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Autores principales: Park, Pojeong, Kang, Heather, Sanderson, Thomas M., Bortolotto, Zuner A., Georgiou, John, Zhuo, Min, Kaang, Bong-Kiun, Collingridge, Graham L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262052/
https://www.ncbi.nlm.nih.gov/pubmed/30524263
http://dx.doi.org/10.3389/fnsyn.2018.00042
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author Park, Pojeong
Kang, Heather
Sanderson, Thomas M.
Bortolotto, Zuner A.
Georgiou, John
Zhuo, Min
Kaang, Bong-Kiun
Collingridge, Graham L.
author_facet Park, Pojeong
Kang, Heather
Sanderson, Thomas M.
Bortolotto, Zuner A.
Georgiou, John
Zhuo, Min
Kaang, Bong-Kiun
Collingridge, Graham L.
author_sort Park, Pojeong
collection PubMed
description Long-term potentiation (LTP) at hippocampal CA1 synapses is classically triggered by the synaptic activation of NMDA receptors (NMDARs). More recently, it has been shown that calcium-permeable (CP) AMPA receptors (AMPARs) can also trigger synaptic plasticity at these synapses. Here, we review this literature with a focus on recent evidence that CP-AMPARs are critical for the induction of the protein kinase A (PKA)- and protein synthesis-dependent component of LTP.
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spelling pubmed-62620522018-12-06 The Role of Calcium-Permeable AMPARs in Long-Term Potentiation at Principal Neurons in the Rodent Hippocampus Park, Pojeong Kang, Heather Sanderson, Thomas M. Bortolotto, Zuner A. Georgiou, John Zhuo, Min Kaang, Bong-Kiun Collingridge, Graham L. Front Synaptic Neurosci Neuroscience Long-term potentiation (LTP) at hippocampal CA1 synapses is classically triggered by the synaptic activation of NMDA receptors (NMDARs). More recently, it has been shown that calcium-permeable (CP) AMPA receptors (AMPARs) can also trigger synaptic plasticity at these synapses. Here, we review this literature with a focus on recent evidence that CP-AMPARs are critical for the induction of the protein kinase A (PKA)- and protein synthesis-dependent component of LTP. Frontiers Media S.A. 2018-11-22 /pmc/articles/PMC6262052/ /pubmed/30524263 http://dx.doi.org/10.3389/fnsyn.2018.00042 Text en Copyright © 2018 Park, Kang, Sanderson, Bortolotto, Georgiou, Zhuo, Kaang and Collingridge. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Park, Pojeong
Kang, Heather
Sanderson, Thomas M.
Bortolotto, Zuner A.
Georgiou, John
Zhuo, Min
Kaang, Bong-Kiun
Collingridge, Graham L.
The Role of Calcium-Permeable AMPARs in Long-Term Potentiation at Principal Neurons in the Rodent Hippocampus
title The Role of Calcium-Permeable AMPARs in Long-Term Potentiation at Principal Neurons in the Rodent Hippocampus
title_full The Role of Calcium-Permeable AMPARs in Long-Term Potentiation at Principal Neurons in the Rodent Hippocampus
title_fullStr The Role of Calcium-Permeable AMPARs in Long-Term Potentiation at Principal Neurons in the Rodent Hippocampus
title_full_unstemmed The Role of Calcium-Permeable AMPARs in Long-Term Potentiation at Principal Neurons in the Rodent Hippocampus
title_short The Role of Calcium-Permeable AMPARs in Long-Term Potentiation at Principal Neurons in the Rodent Hippocampus
title_sort role of calcium-permeable ampars in long-term potentiation at principal neurons in the rodent hippocampus
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262052/
https://www.ncbi.nlm.nih.gov/pubmed/30524263
http://dx.doi.org/10.3389/fnsyn.2018.00042
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