Mineralocorticoid Antagonist Improves Glucocorticoid Receptor Signaling and Dexamethasone Analgesia in an Animal Model of Low Back Pain

Low back pain, a leading cause of disability, is commonly treated by epidural steroid injections that target the anti-inflammatory glucocorticoid receptor (GR). However, their efficacy has been controversial. All currently used epidural steroids also activate the pro-inflammatory mineralocorticoid r...

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Detalles Bibliográficos
Autores principales: Ibrahim, Shaimaa I. A., Xie, Wenrui, Strong, Judith A., Tonello, Raquel, Berta, Temugin, Zhang, Jun-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262081/
https://www.ncbi.nlm.nih.gov/pubmed/30524245
http://dx.doi.org/10.3389/fncel.2018.00453

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