Canary in the Coal Mine? Transmitted Mutations Conferring Resistance to All Integrase Strand Transfer Inhibitors in a Treatment-Naive Patient

Transmitted drug resistance to the integrase strand transfer inhibitor (INSTI) class of antiretrovirals is very rare. We present a case of a treatment-naive female patient with human immunodeficiency virus harboring resistance to all INSTIs, including bictegravir and dolutegravir.

Detalles Bibliográficos
Autores principales: McGee, Kara S, Okeke, Nwora Lance, Hurt, Christopher B, McKellar, Mehri S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262110/
https://www.ncbi.nlm.nih.gov/pubmed/30515433
http://dx.doi.org/10.1093/ofid/ofy294
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author McGee, Kara S
Okeke, Nwora Lance
Hurt, Christopher B
McKellar, Mehri S
author_facet McGee, Kara S
Okeke, Nwora Lance
Hurt, Christopher B
McKellar, Mehri S
author_sort McGee, Kara S
collection PubMed
description Transmitted drug resistance to the integrase strand transfer inhibitor (INSTI) class of antiretrovirals is very rare. We present a case of a treatment-naive female patient with human immunodeficiency virus harboring resistance to all INSTIs, including bictegravir and dolutegravir.
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spelling pubmed-62621102018-12-04 Canary in the Coal Mine? Transmitted Mutations Conferring Resistance to All Integrase Strand Transfer Inhibitors in a Treatment-Naive Patient McGee, Kara S Okeke, Nwora Lance Hurt, Christopher B McKellar, Mehri S Open Forum Infect Dis Brief Report Transmitted drug resistance to the integrase strand transfer inhibitor (INSTI) class of antiretrovirals is very rare. We present a case of a treatment-naive female patient with human immunodeficiency virus harboring resistance to all INSTIs, including bictegravir and dolutegravir. Oxford University Press 2018-11-08 /pmc/articles/PMC6262110/ /pubmed/30515433 http://dx.doi.org/10.1093/ofid/ofy294 Text en © The Author(s) 2018. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
McGee, Kara S
Okeke, Nwora Lance
Hurt, Christopher B
McKellar, Mehri S
Canary in the Coal Mine? Transmitted Mutations Conferring Resistance to All Integrase Strand Transfer Inhibitors in a Treatment-Naive Patient
title Canary in the Coal Mine? Transmitted Mutations Conferring Resistance to All Integrase Strand Transfer Inhibitors in a Treatment-Naive Patient
title_full Canary in the Coal Mine? Transmitted Mutations Conferring Resistance to All Integrase Strand Transfer Inhibitors in a Treatment-Naive Patient
title_fullStr Canary in the Coal Mine? Transmitted Mutations Conferring Resistance to All Integrase Strand Transfer Inhibitors in a Treatment-Naive Patient
title_full_unstemmed Canary in the Coal Mine? Transmitted Mutations Conferring Resistance to All Integrase Strand Transfer Inhibitors in a Treatment-Naive Patient
title_short Canary in the Coal Mine? Transmitted Mutations Conferring Resistance to All Integrase Strand Transfer Inhibitors in a Treatment-Naive Patient
title_sort canary in the coal mine? transmitted mutations conferring resistance to all integrase strand transfer inhibitors in a treatment-naive patient
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262110/
https://www.ncbi.nlm.nih.gov/pubmed/30515433
http://dx.doi.org/10.1093/ofid/ofy294
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