Tenofovir Alafenamide in Multimorbid HIV-Infected Patients With Prior Tenofovir-Associated Renal Toxicity

Although the use of tenofovir alafenamide (TAF), a new prodrug of tenofovir, was safe and efficacious in clinical trials, real-world data from multimorbid individuals are scarce. Among 10 persons living with HIV with previous tenofovir disoproxil fumarate–induced nephrotoxicity, renal function remai...

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Detalles Bibliográficos
Autores principales: Walti, Laura N, Steinrücken, Julia, Rauch, Andri, Wandeler, Gilles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262111/
https://www.ncbi.nlm.nih.gov/pubmed/30515426
http://dx.doi.org/10.1093/ofid/ofy275
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author Walti, Laura N
Steinrücken, Julia
Rauch, Andri
Wandeler, Gilles
author_facet Walti, Laura N
Steinrücken, Julia
Rauch, Andri
Wandeler, Gilles
author_sort Walti, Laura N
collection PubMed
description Although the use of tenofovir alafenamide (TAF), a new prodrug of tenofovir, was safe and efficacious in clinical trials, real-world data from multimorbid individuals are scarce. Among 10 persons living with HIV with previous tenofovir disoproxil fumarate–induced nephrotoxicity, renal function remained stable, and proteinuria decreased in several patients after the switch to TAF.
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spelling pubmed-62621112018-12-04 Tenofovir Alafenamide in Multimorbid HIV-Infected Patients With Prior Tenofovir-Associated Renal Toxicity Walti, Laura N Steinrücken, Julia Rauch, Andri Wandeler, Gilles Open Forum Infect Dis Brief Report Although the use of tenofovir alafenamide (TAF), a new prodrug of tenofovir, was safe and efficacious in clinical trials, real-world data from multimorbid individuals are scarce. Among 10 persons living with HIV with previous tenofovir disoproxil fumarate–induced nephrotoxicity, renal function remained stable, and proteinuria decreased in several patients after the switch to TAF. Oxford University Press 2018-10-24 /pmc/articles/PMC6262111/ /pubmed/30515426 http://dx.doi.org/10.1093/ofid/ofy275 Text en © The Author(s) 2018. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Walti, Laura N
Steinrücken, Julia
Rauch, Andri
Wandeler, Gilles
Tenofovir Alafenamide in Multimorbid HIV-Infected Patients With Prior Tenofovir-Associated Renal Toxicity
title Tenofovir Alafenamide in Multimorbid HIV-Infected Patients With Prior Tenofovir-Associated Renal Toxicity
title_full Tenofovir Alafenamide in Multimorbid HIV-Infected Patients With Prior Tenofovir-Associated Renal Toxicity
title_fullStr Tenofovir Alafenamide in Multimorbid HIV-Infected Patients With Prior Tenofovir-Associated Renal Toxicity
title_full_unstemmed Tenofovir Alafenamide in Multimorbid HIV-Infected Patients With Prior Tenofovir-Associated Renal Toxicity
title_short Tenofovir Alafenamide in Multimorbid HIV-Infected Patients With Prior Tenofovir-Associated Renal Toxicity
title_sort tenofovir alafenamide in multimorbid hiv-infected patients with prior tenofovir-associated renal toxicity
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262111/
https://www.ncbi.nlm.nih.gov/pubmed/30515426
http://dx.doi.org/10.1093/ofid/ofy275
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