The c-Myc/miR17-92/PTEN Axis Tunes PI3K Activity to Control Expression of Recombination Activating Genes in Early B Cell Development

Appropriate PI3K signals generated by the antigen receptor are essential to promote B cell development. Regulation of recombination activating gene (RAG)-1 and RAG-2 expression is one key process that is mediated by PI3K to ensure developmental progression and selection. When PI3K signals are too hi...

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Detalles Bibliográficos
Autores principales: Benhamou, David, Labi, Verena, Getahun, Andrew, Benchetrit, Eli, Dowery, Reem, Rajewsky, Klaus, Cambier, John C., Melamed, Doron
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262168/
https://www.ncbi.nlm.nih.gov/pubmed/30524445
http://dx.doi.org/10.3389/fimmu.2018.02715

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